Background: Currently, a dengue vaccine has been approved in some countries. The problem with this new vaccine is whether the public could accept and be willing to purchase. Objectives: This study aimed to provide solid data regarding factors associated with acceptance and willingness to pay for dengue vaccine. Methods: A systematic review with a meta-analysis was conducted on September-October 2016 for previous studies. Literatures from PubMed and Embase were searched for eligible publications (cut-off date for updates: September 10, 2016). The combined odds ratios (ORs) and 95% confidence intervals (95% CIs) were assessed using random or fixed effect model. Narrative review was used to analyze the data when they were not qualified for meta-analysis. Results: There were several factors associated with acceptance of dengue vaccine including attitude toward vaccination, preventive measures against dengue, attitude towards dengue, knowledge on dengue, socioeconomic level, and dengue experience. However, our meta-analysis revealed that only attitude towards vaccination (OR95%CI = 0.313 [0.137 -0.713], P = 0.006) and socioeconomic level (OR95%CI = 0.576 [0.385 -0.862], P = 0.007) had significant associations with dengue vaccine acceptance. Studies also revealed that preventive measures against dengue, attitude towards dengue, knowledge on dengue fever, knowledge on dengue viruses, socioeconomic levels, dengue experience, and vaccine price were associated with willingness to pay. However, none of those data was qualified for meta-analysis. Conclusions: Meta-analysis reveals that good attitude towards vaccination and higher socioeconomic levels are associated with better acceptance of dengue vaccine.