Strategies for inducing protection against avian influenza A virus subtypes with DNA vaccines

Kodihalli, Shantha; Kobasa, Darwyn; Webster, Robert G.

doi:10.1016/s0264-410x(99)00485-5

Cited by 109 publications

(52 citation statements)

References 22 publications

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“…It is striking that the pandemic H3N2 DNA vaccines are able to induce cross‐reactivity against a strain that has discrepancy in 49 of a total of 129 residues involved in the HA antigenic sites. Cross‐protection and cross‐reactivity by DNA vaccines against viruses differing by 11–13% in the HA1 region have been demonstrated by others 41 , 42 , 43 . Altogether, the overall difference between the glycoproteins may play a minor role compared to the location of the discrepancies 22 .…”

Section: Discussionmentioning

confidence: 75%

Pandemic influenza 1918 H1N1 and 1968 H3N2 DNA vaccines induce cross-reactive immunity in ferrets against infection with viruses drifted for decades

Bragstad

Martel

Thomsen

et al. 2010

Influenza and Other Respiratory Viruses

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Please cite this paper as: Bragstad et al. (2010) Pandemic influenza 1918 H1N1 and 1968 H3N2 DNA vaccines induce cross‐reactive immunity in ferrets against infection with viruses drifted for decades. Influenza and Other Respiratory Viruses 5(1), 13–23. Background Alternative influenza vaccines and vaccine production forms are needed as the conventional protein vaccines do not induce broad cross‐reactivity against drifted strains. Furthermore, fast vaccine production is especially important in a pandemic situation, and broader vaccine reactivity would diminish the need for frequent change in the vaccine formulations. Objective In this study, we compared the ability of pandemic influenza DNA vaccines to induce immunity against distantly related strains within a subtype with the immunity induced by conventional trivalent protein vaccines against homologous virus challenge. Methods Ferrets were immunised by particle‐mediated epidermal delivery (gene gun) with DNA vaccines based on the haemagglutinin (HA) and neuraminidase (NA) and/or the matrix (M) and nucleoprotein genes of the 1918 H1N1 Spanish influenza pandemic virus or the 1968 H3N2 Hong Kong influenza pandemic virus. The animals were challenged with contemporary H1N1 or H3N2 viruses. Results We demonstrated that DNA vaccines encoding proteins of the original 1918 H1N1 pandemic virus induced protective cross‐reactive immune responses in ferrets against infection with a 1947 H1N1 virus and a recent 1999 H1N1 virus. Similarly, a DNA vaccine, based on the HA and NA of the 1968 H3N2 pandemic virus, induced cross‐reactive immune responses against a recent 2005 H3N2 virus challenge. Conclusions DNA vaccines based on pandemic or recent seasonal influenza genes induced cross‐reactive immunity against contemporary virus challenge as good as or superior to contemporary conventional trivalent protein vaccines. This suggests a unique ability of influenza DNA to induce cross‐protective immunity against both contemporary and long‐time drifted viruses.

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Section: Discussionmentioning

confidence: 75%

Pandemic influenza 1918 H1N1 and 1968 H3N2 DNA vaccines induce cross-reactive immunity in ferrets against infection with viruses drifted for decades

Bragstad

Martel

Thomsen

et al. 2010

Influenza and Other Respiratory Viruses

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“…In contrast, a T-cell recall response is delayed in its action (7 to 8 days in mice) but has the advantage of giving broader protection against different influenza virus subtypes. The ability of DNA-based influenza virus vaccination using adenoviral delivery or other methods (1,5,10,13,21,35,36) to induce a T-cell response able to cross-protect at least partially against heterotypic infection could represent an added value, rendering further investigation in the influenza virus recombinant vaccine development field worthwhile. Adenovirus might have some advantages over other DNA-based technologies based on its relatively safe profile, which has been proven through the vaccination of volunteers in more than 100 phase I, II, and III clinical trials.…”

Section: Discussionmentioning

confidence: 99%

Protection of Mice and Poultry from Lethal H5N1 Avian Influenza Virus through Adenovirus-Based Immunization

Gao¹,

Soloff

et al. 2006

J Virol

247

151

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“…DNA vaccines have been shown to elicit humoral and cellular responses and confer protection in small-animal models and in larger species to some degree. 1,[3][4][5][6] Despite these advantages, enhancing the potency of immune responses generated by DNA vaccines is a critical focus of this platform, because DNA vaccines have shown poor translation from rodent studies to human trials. Some strategies to overcome the limitations in immunogenicity of the platform include gene optimization, heterologous prime-boost strategies, improved delivery techniques, as well as the use of molecular adjuvants to augment DNA vaccine-elicited responses.…”

Section: Introductionmentioning

confidence: 99%

Plasmids encoding the mucosal chemokines CCL27 and CCL28 are effective adjuvants in eliciting antigen-specific immunity in vivo

et al. 2009

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A hurdle facing DNA vaccine development is the ability to generate strong immune responses systemically and at local immune sites. We report a novel systemically administered DNA vaccination strategy using intramuscular codelivery of CCL27 or CCL28, which elicited elevated peripheral IFN-g and antigen-specific IgG while driving antigen-specific T-cell secretion of cytokine and antibody production in the gut-associated lymphoid tissue and lung. This strategy resulted in induction of long-lived antibody responses that neutralized influenza A/PR8/34 and protected mice from morbidity and mortality associated with a lethal intranasal viral challenge. This is the first example of the use of CCL27 and CCL28 chemokines as adjuvants to influence a DNA vaccine strategy, suggesting further examination of this approach for manipulation of vaccine-induced immunity impacting both quality and phenotype of responses.

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Strategies for inducing protection against avian influenza A virus subtypes with DNA vaccines

Cited by 109 publications

References 22 publications

Pandemic influenza 1918 H1N1 and 1968 H3N2 DNA vaccines induce cross-reactive immunity in ferrets against infection with viruses drifted for decades

Pandemic influenza 1918 H1N1 and 1968 H3N2 DNA vaccines induce cross-reactive immunity in ferrets against infection with viruses drifted for decades

Protection of Mice and Poultry from Lethal H5N1 Avian Influenza Virus through Adenovirus-Based Immunization

Plasmids encoding the mucosal chemokines CCL27 and CCL28 are effective adjuvants in eliciting antigen-specific immunity in vivo

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