Strategies for interface issues and challenges of neural electrodes

Liang, Cuiyuan; Yan, Liu; Lu, Weihong; Tian, Gongwei; Zhao, Qinyi; Yang, Dan; Sun, Jing; Qi, Dianpeng

doi:10.1039/d1nr07226a

Cited by 23 publications

(21 citation statements)

References 218 publications

(249 reference statements)

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“…Hydrogels can generate ion current through dissolving the ions that were adsorbed in the polymer network of the hydrogel into water. Particularly worth mentioning is the porous structure of hydrogels can provide sufficient space for the doping of other conductive materials, thus further improved the electrochemical properties of the networks without sacrificing hydrogels' biological characteristics (Fu et al, 2020; C. Liang et al, 2022). The Young's modulus of hydrogels is very low that can minimize the mismatch of chemical components between the electronic devices and the biological tissue.…”

Section: Materials For Neural Engineering Interfacementioning

confidence: 99%

“…Ever since the 1960s, neural electroactive interfaces have been applied to record neural signals and stimulate neural tissue in both experimental animals and humans (Evarts, 1966; Marg & Adams, 1967). With the development of new materials and advanced fabrication technologies, more and more new‐type neural interfaces are developed and the interfaces can play a crucial role in treating many debilitating diseases like paralysis, blindness, deafness, epilepsy, and Parkinson's disease (Fattahi et al, 2014; C. Liang et al, 2022). Deep brain stimulation is a typical example of the neural electroactive interfaces.…”

Section: Introductionmentioning

confidence: 99%

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Recent progress of electroactive interface in neural engineering

Shan

Cui

Chen

et al. 2022

WIREs Nanomed Nanobiotechnol

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Neural tissue is an electrical responsible organ. The electricity plays a vital role in the growth and development of nerve tissue, as well as the repairing after diseases. The interface between the nervous system and external device for information transmission is called neural electroactive interface. With the development of new materials and fabrication technologies, more and more new types of neural interfaces are developed and the interfaces can play crucial roles in treating many debilitating diseases such as paralysis, blindness, deafness, epilepsy, and Parkinson's disease. Neural interfaces are developing toward flexibility, miniaturization, biocompatibility, and multifunctionality. This review presents the development of neural electrodes in terms of different materials for constructing electroactive neural interfaces, especially focus on the piezoelectric materials‐based indirect neuromodulation due to their features of wireless control, excellent effect, and good biocompatibility. We discussed the challenges we need to consider before the application of these new interfaces in clinical practice. The perspectives about future directions for developing more practical electroactive interface in neural engineering are also discussed in this review. This article is categorized under: Implantable Materials and Surgical Technologies > Nanomaterials and Implants Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement

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Section: Materials For Neural Engineering Interfacementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent progress of electroactive interface in neural engineering

Shan

Cui

Chen

et al. 2022

WIREs Nanomed Nanobiotechnol

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“…A similar study reported by Shuang et al demonstrated that Tungsten electrodes with nanoporous features showed reduced signal attenuations indicating enhanced consistency as compared with the smother electrodes [ 137 ]. These studies further suggests that the nanoporous materials have greater applications in bioelectronics space, since they have the potential to exhibit excellent electrochemical properties, biocompatibility, and stability [ 138 ].…”

Section: Biomedical Applications Of Nanoporous Materialsmentioning

confidence: 99%

Recent Advancements in the Fabrication of Functional Nanoporous Materials and Their Biomedical Applications

et al. 2022

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Functional nanoporous materials are categorized as an important class of nanostructured materials because of their tunable porosity and pore geometry (size, shape, and distribution) and their unique chemical and physical properties as compared with other nanostructures and bulk counterparts. Progress in developing a broad spectrum of nanoporous materials has accelerated their use for extensive applications in catalysis, sensing, separation, and environmental, energy, and biomedical areas. The purpose of this review is to provide recent advances in synthesis strategies for designing ordered or hierarchical nanoporous materials of tunable porosity and complex architectures. Furthermore, we briefly highlight working principles, potential pitfalls, experimental challenges, and limitations associated with nanoporous material fabrication strategies. Finally, we give a forward look at how digitally controlled additive manufacturing may overcome existing obstacles to guide the design and development of next-generation nanoporous materials with predefined properties for industrial manufacturing and applications.

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“…16,17 Ongoing efforts to mitigate this problem should include developing deformable and conformable materials with favorable electrical properties. 3,18,19 Hydrogels have been gaining growing attention as interfaces between biological and engineered systems due to their tissuelike mechanical properties. 5,20,21 They are promising candidates for neural interfaces since they feature a very low Young's modulus (∼kPa) compared to both thermoplastics and elastomers (∼MPa) and gold and platinum (∼GPa).…”

Section: ■ Introductionmentioning

confidence: 99%

“…The acquisition of neural signals from the brain cortex has always been of high relevance in the field of neuroscience. , Moreover, the extension of the electrophysiological recording/stimulation in the brain cortex from days to years may help understand brain processes and neurological diseases and disorders. − Compared to electroencephalography (EEG), electrocorticography (ECoG) can improve the spatial specificity, amplitude, and signal-to-noise ratio since the electrodes are placed directly on the cortical surface. , ECoG is beneficial in monitoring epilepsy for presurgical planning and is a therapeutic tool for reducing seizures or neuropathic pain. , In addition, due to its high signal-to-noise ratio and localized cortical signal, ECoG can be used for neuroprosthetic research to provide sensory feedback of external devices in the brain–machine interface. − Conventional subdural or epidural electrodes, however, may show immune responses that lead to the fibrous encapsulation of the probe due to a chemomechanical mismatch between the probes and neural tissues. − Conventional solid-state interfaces are not specifically designed to fit the complex mechanical properties of tissues and may injure soft tissues. , Most importantly, an inadequate conformability with the brain cortex might lead to inaccurate signal recordings and potential misdiagnosis. , Ongoing efforts to mitigate this problem should include developing deformable and conformable materials with favorable electrical properties. ,, …”

Section: Introductionmentioning

confidence: 99%

In Vivo Chronic Brain Cortex Signal Recording Based on a Soft Conductive Hydrogel Biointerface

Rinoldi

Ziai

Zargarian

et al. 2022

ACS Appl. Mater. Interfaces

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In neuroscience, the acquisition of neural signals from the brain cortex is crucial to analyze brain processes, detect neurological disorders, and offer therapeutic brain−computer interfaces. The design of neural interfaces conformable to the brain tissue is one of today's major challenges since the insufficient biocompatibility of those systems provokes a fibrotic encapsulation response, leading to an inaccurate signal recording and tissue damage precluding long-term/permanent implants. The design and production of a novel soft neural biointerface made of polyacrylamide hydrogels loaded with plasmonic silver nanocubes are reported herein. Hydrogels are surrounded by a silicon-based template as a supporting element for guaranteeing an intimate neural-hydrogel contact while making possible stable recordings from specific sites in the brain cortex. The nanostructured hydrogels show superior electroconductivity while mimicking the mechanical characteristics of the brain tissue. Furthermore, in vitro biological tests performed by culturing neural progenitor cells demonstrate the biocompatibility of hydrogels along with neuronal differentiation. In vivo chronic neuroinflammation tests on a mouse model show no adverse immune response toward the nanostructured hydrogel-based neural interface. Additionally, electrocorticography acquisitions indicate that the proposed platform permits long-term efficient recordings of neural signals, revealing the suitability of the system as a chronic neural biointerface.

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Strategies for interface issues and challenges of neural electrodes

Abstract: Neural electrodes, as a bridge for bidirectional communication between the body and external devices, are crucial means for detecting and controlling nerve activity. The electrodes play a vital role in...

Cited by 23 publications

References 218 publications

Recent progress of electroactive interface in neural engineering

Recent progress of electroactive interface in neural engineering

Recent Advancements in the Fabrication of Functional Nanoporous Materials and Their Biomedical Applications

In Vivo Chronic Brain Cortex Signal Recording Based on a Soft Conductive Hydrogel Biointerface

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