Strategies for Maintaining Brain Health: The Role of Stroke Risk Factors Unique to Elderly Women

Manwani, Bharti; Finger, Carson; Lisabeth, Lynda D.

doi:10.1161/strokeaha.121.036894

Cited by 3 publications

(1 citation statement)

References 122 publications

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“…Interestingly, when we conducted separate analyses by sex, we found that atrial fibrillation was a significant factor contributing to vascular risk in women, but not in men. This observation is consistent with the existing literature ( 24 , 25 ).…”

Section: Discussionsupporting

confidence: 94%

Baseline characteristics and outcome of stroke patients after endovascular therapy according to previous symptomatic vascular disease and sex

Peycheva,

Padlina,

Genceviciute

et al. 2024

Front. Neurol.

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AimThe aim of this study was to investigate baseline characteristics and outcome of patients after endovascular therapy (EVT) for acute large vessel occlusion (LVO) in relation to their history of symptomatic vascular disease and sex.MethodsConsecutive EVT-eligible patients with LVO in the anterior circulation admitted to our stroke center between 04/2015 and 04/2020 were included in this observational cohort study. All patients were treated according to a standardized acute ischaemic stroke (AIS) protocol. Baseline characteristics and successful reperfusion, recurrent/progressive in-hospital ischaemic stroke, symptomatic in-hospital intracranial hemorrhage, death at discharge and at 3 months, and functional outcome at 3 months were analyzed according to previous symptomatic vascular disease and sex.Results995 patients with LVO in the anterior circulation (49.4% women, median age 76 years, median admission NIHSS score 14) were included. Patients with multiple vs. no previous vascular events showed higher mortality at discharge (20% vs. 9.3%, age/sex − adjustedOR = 1.43, p = 0.030) and less independency at 3 months (28.8% vs. 48.8%, age/sex − adjustedOR = 0.72, p = 0.020). All patients and men alone with one or multiple vs. patients and men with no previous vascular events showed more recurrent/progressive in-hospital ischaemic strokes (19.9% vs. 6.4% in all patients, age/sex − adjustedOR = 1.76, p = 0.028) (16.7% vs. 5.8% in men, age-adjustedOR = 2.20, p = 0.035). Men vs. women showed more in-hospital symptomatic intracranial hemorrhage among patients with one or multiple vs. no previous vascular events (23.7% vs. 6.6% in men and 15.4% vs. 5.5% in women, OR = 2.32, p = 0.035/age − adjustedOR = 2.36, p = 0.035).ConclusionsPrevious vascular events increased the risk of in-hospital complications and poorer outcome in the analyzed patients with EVT-eligible LVO-AIS. Our findings may support risk assessment in these stroke patients and could contribute to the design of future studies.

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Section: Discussionsupporting

confidence: 94%

Baseline characteristics and outcome of stroke patients after endovascular therapy according to previous symptomatic vascular disease and sex

Peycheva,

Padlina,

Genceviciute

et al. 2024

Front. Neurol.

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Understanding risk factors of post-stroke mortality

Castro,

Antonio,

Marreiros

et al. 2025

Neuroscience Informatics

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Short-term exposure to nitrogen dioxide and emergency department visits for cause-stroke: a time-series study in Shanghai, China, 2013–2022

Zhou,

Jin,

Zhang

2024

Environ Health Prev Med

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Background The association between air pollution and an increased risk of cardiovascular diseases, including stroke, is well-established. However, it remains unclear how reductions in pollutant levels—resulting from clean air policies and the COVID-19 lockdown—affect this relationship. Methods A time-series study was conducted using data from Shanghai, China, spanning from 2013 to 2022, divided into two periods (2013–2019 and 2020–2022). Daily air pollution data were obtained from China’s air quality platform, while stroke emergency department (ED) visits were sourced from Renhe Hospital. We employed quasi-Poisson regression to analyze the relationship between daily pollutant levels and stroke ED visits, with stratified analyses by sex, age, season, and period. The study identified significant reductions in six pollutants (PM 2.5 , PM 10–2.5 , PM 10 , SO 2 , NO 2 , CO) during the 2020–2022 period compared to 2013–2019. Results Significant reductions in six air pollutants (NO 2 , PM 2.5 , PM 10–2.5 , PM 10 , SO 2 , CO) were observed during 2020–2022 compared to 2013–2019. Higher daily NO 2 levels were associated with an increased risk of stroke and its subtypes throughout the study, with a stronger correlation observed in the 2020–2022 period ( P < 0.001). Subgroup analyses indicated that females and individuals aged 65–74 experienced the highest risks. The elevated stroke risk was particularly pronounced in the summer during 2020–2022. A two-factor model demonstrated that combined exposure to NO 2 and other pollutants increased stroke risk. Conclusions This study heightened that reduced NO 2 levels generally mitigate the adverse effects of short-term exposure to air pollutants on stroke risk, although the benefits vary among subgroups. The persistent stroke risk despite lower pollutant levels underscores the complex factors influencing stroke risk, highlighting the need for comprehensive intervention strategies. Supplementary information The online version contains supplementary material available at https://doi.org/10.1265/ehpm.24-00304 .

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Strategies for Maintaining Brain Health: The Role of Stroke Risk Factors Unique to Elderly Women

Cited by 3 publications

References 122 publications

Baseline characteristics and outcome of stroke patients after endovascular therapy according to previous symptomatic vascular disease and sex

Baseline characteristics and outcome of stroke patients after endovascular therapy according to previous symptomatic vascular disease and sex

Understanding risk factors of post-stroke mortality

Short-term exposure to nitrogen dioxide and emergency department visits for cause-stroke: a time-series study in Shanghai, China, 2013–2022

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