Strategies for successful designing of immunocontraceptive vaccines and recent updates in vaccine development against sexually transmitted infections - A review

Vickram, A.S.; Dhama, Kuldeep; Thanigaivel, S.; Chakraborty, Sandip; Kannan, Anbarasu; Dey, Nibedita; Karunakaran, Rohini

doi:10.1016/j.sjbs.2022.01.006

Cited by 2 publications

(2 citation statements)

References 237 publications

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“…As the target population for a syphilis vaccine may differ from that of other STI vaccines, considerations must be given to factors such as age, gender, and risk behaviors. Determining the optimal age for vaccination, identifying high-risk groups, and tailoring the vaccine to address specific transmission patterns are critical aspects of designing an effective vaccination strategy [83,87].…”

Section: Development Of Effective Vaccinesmentioning

confidence: 99%

Advancing Syphilis Research: Exploring New Frontiers in Immunology and Pharmacological Interventions

Fajemiroye,

Moreira,

Ito

et al. 2023

Venereology

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In recent years, the global resurgence of syphilis has posed significant challenges to public health. This sexually transmitted infection, caused by the bacterium Treponema pallidum, can have severe consequences if left untreated, including neurological and cardiovascular complications. Diagnosing syphilis is complex due to its diverse clinical presentations, necessitating a multifaceted approach, including serological, molecular, and direct techniques such as dark-field microscopy. Penicillin remains the primary and effective treatment, but emerging macrolide-resistant strains have spurred investigations into alternative antibiotics. Syphilis vaccine development faces unique hurdles, yet promising strategies are under investigation. Targeted prevention strategies focus on high-risk populations such as men who have sex with men, pregnant women, and individuals with multiple sexual partners. The integration of syphilis services into primary healthcare enhances accessibility, early detection, and treatment. Innovative point-of-care diagnostics offer rapid, sensitive testing, while ongoing vaccine research holds the potential for long-term prevention. Addressing the global burden of syphilis requires a multifaceted approach, encompassing immunological advancements, innovative diagnostics, targeted prevention, and primary healthcare integration. Collaborative efforts between governments, healthcare systems, researchers, and communities are essential to effectively combat syphilis, striving toward a syphilis-free future that promotes better sexual health and overall well-being.

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Section: Development Of Effective Vaccinesmentioning

confidence: 99%

Advancing Syphilis Research: Exploring New Frontiers in Immunology and Pharmacological Interventions

Fajemiroye,

Moreira,

Ito

et al. 2023

Venereology

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show abstract

“…This includes investigating different adjuvants, delivery systems, and antigen combinations to elicit a robust and long-lasting immune response. Novel adjuvants and delivery platforms have shown promising results in preclinical studies, providing opportunities for more effective vaccine candidates in the future [46,50].…”

Section: Development Of Effective Vaccinesmentioning

confidence: 99%

Advancing Syphilis Research: Exploring New Frontiers in Immunology and Pharmacological Interventions

Fajemiroye,

Moreira,

Ito

et al. 2023

Preprint

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Syphilis continues to be a significant global health concern, and understanding the latest advancements in immunology and pharmacological treatment is crucial for effective disease management. This review article provides an in-depth exploration of these advancements, aiming to contribute to the growing body of knowledge on syphilis research. The epidemiology of syphilis sets the stage for this review, highlighting the persistent burden of the disease worldwide. Current trends and challenges in disease control are discussed, shedding light on the need for comprehensive prevention strategies and improved surveillance systems. The immunological aspects of syphilis are the focus of this review. The intricate interplay between the host immune response and the evasive strategies employed by Treponema pallidum, the causative agent of syphilis, are explored. These include the mechanisms of immune evasion, the role of adaptive and innate immunity, and the development of immune-mediated tissue damage. The article also highlights advancements in diagnostic methods, with emphasis on the importance of accurate and timely detection. From traditional serological tests to the emergence of novel molecular and point-of-care assays, these developments have significantly improved the efficiency and accuracy of syphilis diagnosis. In terms of pharmacological treatment, the review covers the current recommendations and emerging strategies for managing syphilis infections. The challenges posed by antimicrobial resistance are addressed, emphasizing the importance of appropriate treatment regimens and close monitoring of therapeutic efficacy. Looking to the future, this review highlights the potential of vaccine development as a preventive measure against syphilis. Promising vaccine candidates and ongoing research efforts are discussed, offering hope for an effective means of disease prevention. In conclusion, this comprehensive review explores the advancements in syphilis research, from the understanding of immunological complexities to the development of innovative treatment strategies. By collectively advancing our knowledge, we can strive towards better disease management and minimize the impact of syphilis on global public health.

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Strategies for successful designing of immunocontraceptive vaccines and recent updates in vaccine development against sexually transmitted infections - A review

Cited by 2 publications

References 237 publications

Advancing Syphilis Research: Exploring New Frontiers in Immunology and Pharmacological Interventions

Advancing Syphilis Research: Exploring New Frontiers in Immunology and Pharmacological Interventions

Advancing Syphilis Research: Exploring New Frontiers in Immunology and Pharmacological Interventions

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