Strategies for the functionalisation of gold nanorods to reduce toxicity and aid clinical translation

Shi, Xin; Perry, Hannah L.; Wilton‐Ely, James D. E. T.

doi:10.7150/ntno.56432

Cited by 28 publications

(24 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, polysarconsine-coated GNRs show high colloidal stability, but they have poor surface modification [25]. CuO or MnO2-coated GNRs have facile surface tunability but suffer from cytotoxicity [26,27]. In contrast to these methods, we used polydopamine (PDA) to protect pristine GNR probe from the shape deformation.…”

Section: Introductionmentioning

confidence: 99%

Ultrasmall gold nanorod-polydopamine hybrids for enhanced photoacoustic imaging and photothermal therapy in second near-infrared window

Yim¹,

Borum²,

Zhou³

et al. 2022

Nanotheranostics

View full text Add to dashboard Cite

Gold nanorods (GNRs) have attracted great interest for photo-mediated biomedicines due to their tunable and high optical absorption, high photothermal conversion efficiency and facile surface modifiability. GNRs that have efficient absorption in second near-infrared (NIR-II) window hold further promise in bio-applications due to low background signal from tissue and deep tissue penetration. However, bare GNRs readily undergo shape deformation (termed as 'melting effect') during the laser illumination losing their unique localized surface plasmon resonance (LSPR) properties, which subsequently leads to PA signal attenuation and decreased photothermal efficiency. Polydopamine (PDA) is a robust synthetic melanin that has broad absorption and high photothermal conversion. Herein, we coated GNRs with PDA to prepare photothermally robust GNR@PDA hybrids for enhanced photo-mediated theranostic agents. Ultrasmall GNRs (SGNRs) and conventional large GNRs (LGNRs) that possess similar LSPR characteristics as well as GNR@PDA hybrids were compared side-by-side in terms of the size-dependent photoacoustic (PA) imaging, photothermal therapy (PTT), and structural stability. In vitro experiments further demonstrated that SGNR@PDA showed 95% ablation of SKOV3 ovarian cancer cells, which is significantly higher than that of LGNRs (66%) and SGNRs (74%). Collectively, our PDA coating strategy represents a rational design for enhanced PA imaging and efficient PTT via a nanoparticle, i.e., nanotheranostics.

show abstract

Section: Introductionmentioning

confidence: 99%

Ultrasmall gold nanorod-polydopamine hybrids for enhanced photoacoustic imaging and photothermal therapy in second near-infrared window

Yim¹,

Borum²,

Zhou³

et al. 2022

Nanotheranostics

View full text Add to dashboard Cite

show abstract

“…CTAB coordinating with another mild reducing agent could obtain anisotropic AuNPs, which is vital for potential applications in SERS. However, its high cytotoxicity is a major concern, and in a biological setting, the CTAB layer must either be exchanged or encapsulated (Shi et al, 2021). Polyethylene glycol (PEG) (Huckaby and Lai, 2018) is another commonly used stabilizer prolonging the blood circulation time in vivo.…”

Section: Stabilizationmentioning

confidence: 99%

Gold Nanoparticles in Cancer Theranostics

Gao

Zhang

Gao

et al. 2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Conventional cancer treatments, such as surgical resection, radiotherapy, and chemotherapy, have achieved significant progress in cancer therapy. Nevertheless, some limitations (such as toxic side effects) are still existing for conventional therapies, which motivate efforts toward developing novel theranostic avenues. Owning many merits such as easy surface modification, unique optical properties, and high biocompatibility, gold nanoparticles (AuNPs and GNPs) have been engineered to serve as targeted delivery vehicles, molecular probes, sensors, and so on. Their small size and surface characteristics enable them to extravasate and access the tumor microenvironment (TME), which is a promising solution to realize highly effective treatments. Moreover, stimuli-responsive properties (respond to hypoxia and acidic pH) of nanoparticles to TME enable GNPs’ unrivaled control for effective transport of therapeutic cargos. In this review article, we primarily introduce the basic properties of GNPs, further discuss the recent progress in gold nanoparticles for cancer theranostics, with an additional concern about TME stimuli-responsive studies.

show abstract

“…Since the removal of CTAB causes instability of GNR suspensions, a major challenge is to prevent GNR aggregation while maintaining a low toxicity profile [45]. To solve this issue, several researchers exchanged the CTAB layers with more biocompatible ligands, such as thiolated polyethylene glycol (PEG) [46], 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) phospholipid molecules, ref.…”

Section: Introductionmentioning

confidence: 99%

Improvements in Gold Nanorod Biocompatibility with Sodium Dodecyl Sulfate Stabilization

Terracciano

Zhang

Simeral

et al. 2021

JNT

View full text Add to dashboard Cite

Due to their well-defined plasmonic properties, gold nanorods (GNRs) can be fabricated with optimal light absorption in the near-infrared region of the electromagnetic spectrum, which make them suitable for cancer-related theranostic applications. However, their controversial safety profile, as a result of surfactant stabilization during synthesis, limits their clinical translation. We report a facile method to improve GNR biocompatibility through the presence of sodium dodecyl sulfate (SDS). GNRs (120 × 40 nm) were synthesized through a seed-mediated approach, using cetyltrimethylammonium bromide (CTAB) as a cationic surfactant to direct the growth of nanorods and stabilize the particles. Post-synthesis, SDS was used as an exchange ligand to modify the net surface charge of the particles from positive to negative while maintaining rod stability in an aqueous environment. GNR cytotoxic effects, as well as the mechanisms of their cellular uptake, were examined in two different cancer cell lines, Lewis lung carcinoma (LLC) and HeLa cells. We not only found a significant dose-dependent effect of GNR treatment on cell viability but also a time-dependent effect of GNR surfactant charge on cytotoxicity over the two cell lines. Our results promote a better understanding of how we can mediate the undesired consequences of GNR synthesis byproducts when exposed to a living organism, which so far has limited GNR use in cancer theranostics.

show abstract

Strategies for the functionalisation of gold nanorods to reduce toxicity and aid clinical translation

Cited by 28 publications

References 65 publications

Ultrasmall gold nanorod-polydopamine hybrids for enhanced photoacoustic imaging and photothermal therapy in second near-infrared window

Ultrasmall gold nanorod-polydopamine hybrids for enhanced photoacoustic imaging and photothermal therapy in second near-infrared window

Gold Nanoparticles in Cancer Theranostics

Improvements in Gold Nanorod Biocompatibility with Sodium Dodecyl Sulfate Stabilization

Contact Info

Product

Resources

About