Strategies for the prevention, diagnosis and treatment of COPD in low- and middle- income countries: the importance of primary care

Rossaki, Foteini M; Hurst, John R.; Gemert, Frederik van; Kirenga, Bruce; Williams, Siân; Khoo, Ee Ming; Tsiligianni, Ioanna; Tabyshova, Aizhamal; Boven, Job F M van

doi:10.1080/17476348.2021.1985762

Cited by 27 publications

(25 citation statements)

References 84 publications

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“…COPD prevalence is estimated to be higher in HICs; however, most absolute cases are projected to be in LMICs both now and in the future, which aligns with previous studies showing that more than three-quarters of global COPD cases exist in LMICs. 7,20,21 By 2050, the number of people with COPD in LMICs is expected to be more than double that of HICs. For example, we projected a 59% increase in COPD cases in sub-Saharan Africa, which will surpass other world regions in both COPD prevalence and cases by 2040.…”

Section: Discussionmentioning

confidence: 99%

Global Burden of Chronic Obstructive Pulmonary Disease Through 2050

Boers,

Barrett,

et al. 2023

JAMA Netw Open

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ImportanceChronic obstructive pulmonary disease (COPD) is a respiratory condition that is associated with significant health and economic burden worldwide. Previous studies assessed the global current-day prevalence of COPD, but to better facilitate resource planning and intervention development, long-term projections are needed.ObjectiveTo assess the global burden of COPD through 2050, considering COPD risk factors.Design, Setting, and ParticipantsIn this modeling study, historical data on COPD prevalence was extracted from a recent meta-analysis on 2019 global COPD prevalence, and 2010 to 2018 historical prevalence was estimated using random-effects meta-analytical models. COPD risk factor data were obtained from the Global Burden of Disease database.Main Outcomes and MeasuresTo project global COPD prevalence to 2050, generalized additive models were developed, including smoking prevalence, indoor and outdoor air pollution, and development indices as predictors, and stratified by age, sex, and World Bank region.ResultsThe models estimated that the number of COPD cases globally among those aged 25 years and older will increase by 23% from 2020 to 2050, approaching 600 million patients with COPD globally by 2050. Growth in the burden of COPD was projected to be the largest among women and in low- and middle-income regions. The number of female cases was projected to increase by 47.1% (vs a 9.4% increase for males), and the number of cases in low- and middle-income regions was expected to be more than double that of high-income regions by 2050.Conclusions and RelevanceIn this modeling study of future COPD burden, projections indicated that COPD would continue to affect hundreds of millions of people globally, with disproportionate growth among females and in low-middle income regions through 2050. Further research, prevention, and advocacy are needed to address these issues so that adequate preparation and resource allocation can take place.

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Section: Discussionmentioning

confidence: 99%

Global Burden of Chronic Obstructive Pulmonary Disease Through 2050

Boers,

Barrett,

et al. 2023

JAMA Netw Open

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“…The true prevalence and burden of respiratory problems, especially symptoms, in individual LMICs remains poorly understood. In the absence of primary care data at the general population level, new knowledge of the epidemiology of respiratory problems in LMICs mostly comes from prevalence surveys [13].…”

Section: True Prevalence Of Respiratory Diseasesmentioning

confidence: 99%

Burden of respiratory problems in low-income and middle-income countries

Clark

Kochovska

Currow

2022

Current Opinion in Supportive &Amp; Palliative Care

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Purpose of reviewChronic respiratory diseases are a leading cause of morbidity and mortality in low-income and middleincome countries (LMICs). We aim to review prevalence of respiratory diseases and related symptoms, which contribute significantly to burden of disease in LMICs. We report global estimates of respiratory problems amongst adults in LMICs and recent findings relating to community prevalence and impact of respiratory problems. We conclude by identifying research priorities for improved recognition and palliation of respiratory problems. Recent findingsWe report findings from 16 studies, highlighting key issues relevant to burden of respiratory problems in LMICs. COPD and associated symptoms are identified as important drivers of increasing respiratory problems in LMICs, with an estimated prevalence of 7.2%. Negative impacts of respiratory diseases include: reduced physical function (capacity to work), quality of life (depression; anxiety) and socioeconomic wellbeing (healthcare costs; earning potential). Locally appropriate palliative care interventions may improve quality of life without increasing costs.

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“…Chronic obstructive pulmonary disease (COPD) is the most frequent non-communicable incurable lung disease with a high mortality rate, mainly in low-income countries. 1 Most patients with COPD receive broad-spectrum antimicrobials and corticosteroids, and have high susceptibility to pulmonary aspergillosis. 2,3 Chronic pulmonary aspergillosis (CPA) is often misdiagnosed, especially among patients with COPD.…”

Section: Introductionmentioning

confidence: 99%

Impact of Ascaris lumbricoides infection on the development of chronic pulmonary aspergillosis in patients with COPD

Toychiev,

Gafner,

Belotserkovets

et al. 2024

Trop Doct

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The aetiopathogenesis of chronic obstructive pulmonary disease (COPD) remains unclear. The aim of our study was to determine the possible influence of Ascaris lumbricoides on the development of chronic pulmonary aspergillosis (CPA) in patients with COPD. The prevalence of A. lumbricoides in patients with COPD with CPA (19.05%) was significantly higher than that in those without (9.20%) and controls (4.9%) ( p < 0.05). Trends in levels of Interleukin-1β and of tumour necrosis factor α suggest ascariasis increases susceptibility to Aspergillus sp. in patients with COPD and can be considered an additional risk factor for CPA.

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Strategies for the prevention, diagnosis and treatment of COPD in low- and middle- income countries: the importance of primary care

Cited by 27 publications

References 84 publications

Global Burden of Chronic Obstructive Pulmonary Disease Through 2050

Global Burden of Chronic Obstructive Pulmonary Disease Through 2050

Burden of respiratory problems in low-income and middle-income countries

Impact of Ascaris lumbricoides infection on the development of chronic pulmonary aspergillosis in patients with COPD

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