Strategies for Tumor Hypoxia Imaging Based on Aggregation‐Induced Emission Fluorogens

Xue, Tianhao; Shen, Jiajia; Shao, Kuanchun; Wang, Wei; Wu, Bing; He, Yaning

doi:10.1002/chem.201904327

Cited by 35 publications

(18 citation statements)

References 57 publications

(108 reference statements)

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“…Effective control of molecular assembly has promisinga pplications in differentt echnological and scientific fields. For instance, someb iomedical applications, such as biosensing, bioimaging, [14][15][16][17][18][19] and gene and drug delivery, [2,20,21] are based on molecular self-assembled systems. In addition, the crystal packing adopted by p-conjugatedc ompounds determines their electronic andp hotophysicalp roperties and their later use in light-emitting electronic devices, [1,14,15] chemiresistives ensors, [15,22] agricultural films, [23] among others.…”

Section: Introductionmentioning

confidence: 99%

Understanding the Driving Mechanisms of Enhanced Luminescence Emission of Oligo(styryl)benzenes and Tri(styryl)‐s‐triazine

Domínguez

Moral

Fernández‐Liencres

et al. 2020

Chemistry A European J

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This work is focused on unraveling the mechanisms responsible for the aggregation‐induced enhanced emission and solid‐state luminescence enhancement effects observed in star‐shaped molecules based on 1,3,5‐tris(styryl)benzene and tri(styryl)‐s‐triazine cores. To achieve this, the photophysical properties of this set of molecules were analyzed in three states: free molecules, molecular aggregates in solution, and the solid state. Different spectroscopy and microscopy experiments and DFT calculations were conducted to scrutinize the causative mechanisms of the luminescence enhancement phenomenon observed in some experimental conditions. Enhanced luminescence emission was interpreted in the context of short‐ and long‐range excitonic coupling mechanisms and the restriction of intramolecular vibrations. Additionally, we found that the formation of π‐stacking aggregates could block E/Z photoisomerization through torsional motions between phenylene rings in the excited state, and hence, enhancing the luminescence of the system.

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Section: Introductionmentioning

confidence: 99%

Understanding the Driving Mechanisms of Enhanced Luminescence Emission of Oligo(styryl)benzenes and Tri(styryl)‐s‐triazine

Domínguez

Moral

Fernández‐Liencres

et al. 2020

Chemistry A European J

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“…In fact, tumor cells prefer aerobic glycolysis to obtain energy rather than the conventional oxidative phosphorylation pathway due to the Warburg effect. Therefore, many enzymes related to electron donation or reduction response are overgenerated in hypoxic tumor cells, such as azoreductase, nitroreductase, methionine synthase reductase, inducible nitric synthase and DT-diaphorase (DTD) [ 274 , 275 ]. Hence, considerable efforts have been made to develop hypoxia-responsive nanoplatforms that can be activated by these enzymes for enhanced tumor treatment based on the above findings [ 274 , 276 , 277 ].…”

Section: Stimuli-responsive Targeting Strategiesmentioning

confidence: 99%

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

et al. 2022

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Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one of the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving the therapeutic potential of various agents and bioactive molecules through the enhanced permeability and retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective delivery to the tumor cells utilizing cell surface-specific receptors, the tumor vasculature and antigens with high accuracy and affinity. Additionally, stimuli-responsive nanoplatforms have also been considered as a promising and effective targeting strategy against tumors, as these nanoplatforms maintain their stealth feature under normal conditions, but upon homing in on cancerous lesions or their microenvironment, are responsive and release their cargoes. In this review, we comprehensively summarize the field of active targeting drug delivery systems and a number of stimuli-responsive release studies in the context of emerging nanoplatform development, and also discuss how this knowledge can contribute to further improvements in clinical practice.

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“…The incidence and mortality rates of cancer are increasing rapidly in countries around the world [ 1 , 2 ]. Cancer is a mortal disease that is relatively difficult to cure because of its uncontrollable and ultrafast proliferation properties [ 3 , 4 ]. Thus, it is of profound significance for human health to explore highly effective and active therapeutic approaches for cancer.…”

Section: Introductionmentioning

confidence: 99%

Aggregation-induced emission photosensitizer-based photodynamic therapy in cancer: from chemical to clinical

et al. 2022

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Cancer remains a serious threat to human health owing to the lack of effective treatments. Photodynamic therapy (PDT) has emerged as a promising non-invasive cancer treatment that consists of three main elements: photosensitizers (PSs), light and oxygen. However, some traditional PSs are prone to aggregation-caused quenching (ACQ), leading to reduced reactive oxygen species (ROS) generation capacity. Aggregation-induced emission (AIE)-PSs, due to their distorted structure, suppress the strong molecular interactions, making them more photosensitive in the aggregated state instead. Activated by light, they can efficiently produce ROS and induce cell death. PS is one of the core factors of efficient PDT, so proceeding from the design and preparation of AIE-PSs, including how to manipulate the electron donor (D) and receptor (A) in the PSs configuration, introduce heavy atoms or metal complexes, design of Type I AIE-PSs, polymerization-enhanced photosensitization and nano-engineering approaches. Then, the preclinical experiments of AIE-PSs in treating different types of tumors, such as ovarian cancer, cervical cancer, lung cancer, breast cancer, and its great potential clinical applications are discussed. In addition, some perspectives on the further development of AIE-PSs are presented. This review hopes to stimulate the interest of researchers in different fields such as chemistry, materials science, biology, and medicine, and promote the clinical translation of AIE-PSs. Graphical Abstract

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Strategies for Tumor Hypoxia Imaging Based on Aggregation‐Induced Emission Fluorogens

Cited by 35 publications

References 57 publications

Understanding the Driving Mechanisms of Enhanced Luminescence Emission of Oligo(styryl)benzenes and Tri(styryl)‐s‐triazine

Understanding the Driving Mechanisms of Enhanced Luminescence Emission of Oligo(styryl)benzenes and Tri(styryl)‐s‐triazine

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

Aggregation-induced emission photosensitizer-based photodynamic therapy in cancer: from chemical to clinical

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