“…The clinical justification for using hormone stimulation therapy is that it can potentially increase intratesticular testosterone (ITT), which is required for spermiogenesis. The ITT level has been reported to be significantly higher than serum testosterone level, with reports varying from 100 to 1000 times 8 . However, the only method to measure ITT is using testicular aspiration, which is an invasive procedure, and thus hormone stimulation therapy has been utilised empirically 8 .…”