Strategies to encourage the adoption of social housing during cardiovascular telemetry recordings in non-rodents

Prior, Helen; Holbrook, Mark

doi:10.1016/j.vascn.2021.106959

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…This article highlights a number of refinements that can be adopted to reduce the time that an animal is separated from companions, with the recognition that social housing generally provides the best enrichment opportunity for the laboratory species used within toxicology packages. These can be simple changes via shorter blood sampling protocols if microsampling is adopted, or changes in technologies or equipment for collection of data from group housed animals [ 24 , 25 , 26 , 27 ]. Importantly, the data collected from group housed animals is the same or better quality and variability than historical data from animals housed individually.…”

Section: Discussionmentioning

confidence: 99%

“…For example, recording of dog or NHP ECGs via jacketed telemetry within the home pen, instead of removing the animal to a separate room for ‘snap-shot’ ECGs (the telemetry technique also provides more and higher quality data). Recordings from surgically-implanted telemetry devices can now be made from multiple animals within the same cage/pen for both rodents and non-rodents, reducing the need for individual housing during safety pharmacology and toxicology studies collecting cardiovascular and other data [ 24 , 25 ]. Rats, dogs, and NHPs are also isolated for collection of urine and feces for metabolism studies.…”

Section: Introductionmentioning

confidence: 99%

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Refining Procedures within Regulatory Toxicology Studies: Improving Animal Welfare and Data

Prior

Blunt²,

Crossman³

et al. 2021

Animals

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During the development of potential new medicines or agrochemicals, an assessment of the safety profile to humans and environmental species is conducted using a range of different in silico and in vitro techniques in conjunction with metabolism and toxicity studies using animals. The required studies are outlined within international regulatory guidelines which acknowledge and support the application of the 3Rs to reduce the number of animals used or to refine the procedures performed when these studies are deemed to be necessary. The continued development of new technologies and adoption of best-practice approaches to laboratory animal housing and study procedures has generated a series of refinements that can be incorporated into animal studies throughout the package. These refinements benefit the welfare of fish, mice, rats, rabbits, dogs, minipigs, and non-human primates (NHPs) whilst maintaining or improving data quality within general toxicology, metabolism, and other studies and can also bring efficiencies to processes that benefit study costs and timings. Examples are shared which cover the following topics: social housing of dogs and NHPs, surgical refinements in the rat bile duct cannulation model for collection of data for metabolism studies, whether fasting is really required prior to clinical pathology sampling, and the use of microsampling for toxicokinetics.

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