Strategies to Expand the Deceased Donor Pool for Pediatric Kidney Transplant Recipients

Kizilbash, Sarah J.; Chavers, Blanche M.

doi:10.34067/kid.0001772020

Cited by 4 publications

(3 citation statements)

References 14 publications

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“…34,35 In 2018, one-fifth of adult deceased donor kidney transplants were DCD transplants. 6 Despite the increasing use in adults, only 2.5% of children in our cohort received a DCD transplant. A common deterrent to accepting a DCD kidney for a child is the perceived lack of benefit of DCD transplantation considering pediatric priority for organ allocation.…”

Section: Discussionmentioning

confidence: 78%

“…Despite the dire shortage, 20% of the recovered organs are annually discarded in the United States. 6 Kidneys donated after circulatory death (DCD) have a high rate of discard. 6 Because DCD donors undergo organ retrieval after circulatory arrest, tissue ischemia sustained by these organs increases the likelihood of primary nonfunction and/or delayed graft function.…”

Section: Introductionmentioning

confidence: 99%

“…6 Kidneys donated after circulatory death (DCD) have a high rate of discard. 6 Because DCD donors undergo organ retrieval after circulatory arrest, tissue ischemia sustained by these organs increases the likelihood of primary nonfunction and/or delayed graft function. As a result, DCD kidneys are perceived as being less desirable for transplantation.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Survival Benefit of Donation After Circulatory Death Kidney Transplantation in Children Compared With Remaining on the Waiting List for a Kidney Donated After Brain Death

2021

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The data reported here have been supplied by the Hennepin Healthcare Research Institute as the contractor for the Scientific Registry of Transplant Recipients (SRTR). The interpretation and reporting of these data are the responsibility of the author(s) and in no way should be seen as an official policy of or interpretation by the SRTR or the US Government. S.J.K. participated in study design, data analysis, and writing of the article. B.M.C. participated in study design and writing of the article. M.D.E. participated in data analysis and writing of the article.

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Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Survival Benefit of Donation After Circulatory Death Kidney Transplantation in Children Compared With Remaining on the Waiting List for a Kidney Donated After Brain Death

2021

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Pretransplant Donor and Recipient Infectious Challenges

Kizilbash

Smith

2021

Challenges in Pediatric Kidney Transplantation

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Machine Perfusion and Bioengineering Strategies in Transplantation—Beyond the Emerging Concepts

Niroomand,

Nita,

Lindstedt

2024

Transpl Int

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Solid organ transplantation has progressed rapidly over the decades from the first experimental procedures to its role in the modern era as an established treatment for end-stage organ disease. Solid organ transplantation including liver, kidney, pancreas, heart, and lung transplantation, is the definitive option for many patients, but despite the advances that have been made, there are still significant challenges in meeting the demand for viable donor grafts. Furthermore, post-operatively, the recipient faces several hurdles, including poor early outcomes like primary graft dysfunction and acute and chronic forms of graft rejection. In an effort to address these issues, innovations in organ engineering and treatment have been developed. This review covers efforts made to expand the donor pool including bioengineering techniques and the use of ex vivo graft perfusion. It also covers modifications and treatments that have been trialed, in addition to research efforts in both abdominal organs and thoracic organs. Overall, this article discusses recent innovations in machine perfusion and organ bioengineering with the aim of improving and increasing the quality of donor organs.

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Strategies to Expand the Deceased Donor Pool for Pediatric Kidney Transplant Recipients

Cited by 4 publications

References 14 publications

Survival Benefit of Donation After Circulatory Death Kidney Transplantation in Children Compared With Remaining on the Waiting List for a Kidney Donated After Brain Death

Survival Benefit of Donation After Circulatory Death Kidney Transplantation in Children Compared With Remaining on the Waiting List for a Kidney Donated After Brain Death

Pretransplant Donor and Recipient Infectious Challenges

Machine Perfusion and Bioengineering Strategies in Transplantation—Beyond the Emerging Concepts

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