Strategies to improve bioactive and antibacterial properties of polyetheretherketone (PEEK) for use as orthopedic implants

Zheng, Zhi; Liu, Pengjia; Zhang, Xingmin; xin, Jingguo; wang, Yongjie; Zou, Xiaosong; Mei, Xiaohan; Zhang, Shuling; Zhang, Shaokun

doi:10.1016/j.mtbio.2022.100402

Cited by 65 publications

(50 citation statements)

References 316 publications

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“…Additionally, PEEK has the advantages of good biocompatibility and elastic modulus similar to that of normal human bone and can be compounded with glass or carbon fibers to prepare reinforcing materials for bone tissue repair, but the biological inertness of PEEK limits its application in the field of bone repair [ 93 ]. Therefore, in recent years, scholars at home and abroad have conducted extensive research on the modification of polyetheretherketone materials, aiming to improve their bioactivity and osseointegration properties in order to play a good medical role in cranial bone repair and vertebral bone repair [ 94 , 95 , 96 ].…”

Section: Synthetic Polymersmentioning

confidence: 99%

Recent Advances in the Application of Natural and Synthetic Polymer-Based Scaffolds in Musculoskeletal Regeneration

et al. 2022

Polymers

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The musculoskeletal system plays a critical role in providing the physical scaffold and movement to the mammalian body. Musculoskeletal disorders severely affect mobility and quality of life and pose a heavy burden to society. This new field of musculoskeletal tissue engineering has great potential as an alternative approach to treating large musculoskeletal defects. Natural and synthetic polymers are widely used in musculoskeletal tissue engineering owing to their good biocompatibility and biodegradability. Even more promising is the use of natural and synthetic polymer composites, as well as the combination of polymers and inorganic materials, to repair musculoskeletal tissue. Therefore, this review summarizes the progress of polymer-based scaffolds for applications of musculoskeletal tissue engineering and briefly discusses the challenges and future perspectives.

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Section: Synthetic Polymersmentioning

confidence: 99%

Recent Advances in the Application of Natural and Synthetic Polymer-Based Scaffolds in Musculoskeletal Regeneration

et al. 2022

Polymers

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“…In addition, an antibacterial adhesion coating can also become multifunctional by adding other components. The following is introduced depending on whether the function is single or multiple [ 111 , 112 , 113 , 114 , 115 , 116 , 123 ].…”

Section: Anti-adhesion Strategies For Titanium Implantsmentioning

confidence: 99%

Antibacterial Adhesion Strategy for Dental Titanium Implant Surfaces: From Mechanisms to Application

Zhou

Zhang

et al. 2022

JFB

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Dental implants are widely used to restore missing teeth because of their stability and comfort characteristics. Peri-implant infection may lead to implant failure and other profound consequences. It is believed that peri-implantitis is closely related to the formation of biofilms, which are difficult to remove once formed. Therefore, endowing titanium implants with anti-adhesion properties is an effective method to prevent peri-implant infection. Moreover, anti-adhesion strategies for titanium implant surfaces are critical steps for resisting bacterial adherence. This article reviews the process of bacterial adhesion, the material properties that may affect the process, and the anti-adhesion strategies that have been proven effective and promising in practice. This article intends to be a reference for further improvement of the antibacterial adhesion strategy in clinical application and for related research on titanium implant surfaces.

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“…PEEK, which exhibits many desirable properties, e.g., elastic modulus, strength, wear resistance, radiolucency, and biocompatibility, has been used to manufacture maxillofacial and spinal implants. Drawbacks include its bioinert and hydrophobic properties, and its susceptibility to microbial infections [ 83 ].…”

Section: Infection Control and Orthopaedic Implant Designmentioning

confidence: 99%

Strategies to Mitigate and Treat Orthopaedic Device-Associated Infections

et al. 2022

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Orthopaedic device implants play a crucial role in restoring functionality to patients suffering from debilitating musculoskeletal diseases or to those who have experienced traumatic injury. However, the surgical implantation of these devices carries a risk of infection, which represents a significant burden for patients and healthcare providers. This review delineates the pathogenesis of orthopaedic implant infections and the challenges that arise due to biofilm formation and the implications for treatment. It focuses on research advancements in the development of next-generation orthopaedic medical devices to mitigate against implant-related infections. Key considerations impacting the development of devices, which must often perform multiple biological and mechanical roles, are delineated. We review technologies designed to exert spatial and temporal control over antimicrobial presentation and the use of antimicrobial surfaces with intrinsic antibacterial activity. A range of measures to control bio-interfacial interactions including approaches that modify implant surface chemistry or topography to reduce the capacity of bacteria to colonise the surface, form biofilms and cause infections at the device interface and surrounding tissues are also reviewed.

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Strategies to improve bioactive and antibacterial properties of polyetheretherketone (PEEK) for use as orthopedic implants

Cited by 65 publications

References 316 publications

Recent Advances in the Application of Natural and Synthetic Polymer-Based Scaffolds in Musculoskeletal Regeneration

Recent Advances in the Application of Natural and Synthetic Polymer-Based Scaffolds in Musculoskeletal Regeneration

Antibacterial Adhesion Strategy for Dental Titanium Implant Surfaces: From Mechanisms to Application

Strategies to Mitigate and Treat Orthopaedic Device-Associated Infections

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