Strategies to Improve Biocompatibility of Dental Materials

Abstract

Adverse reactions to dental materials occur and public interest in this topic has increased during recent decades. Thus, improving the biocompatibility of dental materials is necessary and must be based on several strategies. First, a strategy for improving the administrative and technical conditions for material certification processes should be included, such as the development of in vitro tests with enhanced predictability of the generated data for use in the clinic. Second, research on material/tissue interactions must be enhanced and include mechanistic approaches, as this strategy leads to the development of new and more biocompatible materials. Research into patients and their individual exposure situation is a strategy directed at better defining risk groups. Finally, improvement of education will also lead to improved biocompatibility of dental materials.

Effects of bleaching agents on surface roughness of filling materials

“…Bleaching is based upon hydrogen peroxide as the active agent, which may be applied directly or released by a chemical reaction from carbamide peroxide 2) . The latter acts as a deposit material releasing hydrogen peroxide and urea 3) . While carbamide peroxide formulations are mostly used in supervised home bleaching, higher concentrations of hydrogen peroxide up to 35% are recommended for in-office bleaching and non-vital bleaching.…”

The influence of three endodontic sealers on bone healing: an experimental study

“…As there is a well-documented model for the assessment of bone healing, experimental studies on the rat skull is the gold standard for testing tissue reaction to root canal filling material [3,13,14]. For each group, the control orifice was 1 of the 4 orifices made in the calvaria, which was free of any tested material.…”

Di̇şheki̇mli̇ği̇nde Bi̇youyumluluk Ve Değerlendi̇rme Yöntemleri̇

“…Örneğin; 24 saat içerisinde akut sistemik toksisite gösteren bir materyal, 3 ay sonra subakut ve daha uzun sürede kronik sistemik toksisite sergileyebilmektedir. [6][7][8][9] Dental materyallerin biyouyumluğunun değerlendirilmesi; hasta ve sağlık ekibinin güvenliğini sağlamaya yönelik bir çaba olup, çeşitli biyolojik ve fiziksel özellik testleri ile riskfayda analizi konularını kapsar. Yapılacak analizlerin, materyallerden salınan bileşenlerin canlı dokularla her türlü ilişkisini ortaya koyması oldukça önemlidir.…”

“…Bu sayede, insan ve hayvanlar acı çekme potansiyeline karşı korunmuş olmakla birlikte, zaman ve para tasarrufu da sağlanmaktadır. 4,5,14,15 A. İN-VİTRO (BiRİNCİL) TESTLER Sitotoksisite testinde; dental materyalin kendisi veya yapısından salınan bileşenlerin hücre kültürü ile direkt veya indirekt kontağı söz konusudur. Direkt temas yönteminde, hücreler materyalin yanında veya üzerinde büyümekte ve biyolojik hücre ölümleri değerlendirilmektedir.…”