Strategies to improve the diagnosis and clinical treatment of dermatophyte infections

Durdu, Murat; İlkit, Macit

doi:10.1080/14787210.2023.2144232

Cited by 5 publications

(2 citation statements)

References 78 publications

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“…The estimated risk of developing dermatophytosis throughout human life is 10-20% [32]. Given the prevalence of dermatophytes and the high rates of infection, proper diagnosis and treatment are extremely important [33]. The study population was dominated by females.…”

Section: Discussionmentioning

confidence: 99%

Superficial Zoonotic Mycoses in Humans Associated with Cats

Piorunek,

Kubisiak-Rzepczyk,

Dańczak-Pazdrowska

et al. 2024

JoF

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Dermatophytosis is a superficial fungal skin infection common in humans around the world and is one of the many zoonotic skin diseases that cat owners are at risk of contracting. This retrospective study was conducted based on a detailed analysis of the results of mycological examination and medical documentation of 56 patients diagnosed with cat-to-human dermatophytoses from January 2017 to July 2022. Zoonotic mycoses were diagnosed more frequently in young people and women. In children, lesions most often occurred in the scalp area, and in adults, in the glabrous skin area. Skin infections caused by Microsporum canis (M. canis) prevailed and were confirmed in 47 patients (83.9%). Trichophyton mentagrophytes (T. mentagrophytes) was found in nine (16.1%) patients. M. canis predominantly caused infections of the scalp, followed by lower limb infections. Hairy scalps were almost exclusively involved in children. The odds of diagnosing M. canis infection compared to T. mentagrophytes infection was significantly higher in the head than in other regions, especially among children. The positive predictive value of a direct macroscopic examination was relatively low.

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Section: Discussionmentioning

confidence: 99%

Superficial Zoonotic Mycoses in Humans Associated with Cats

Piorunek,

Kubisiak-Rzepczyk,

Dańczak-Pazdrowska

et al. 2024

JoF

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“…By diversifying the available treatments and mechanisms of action, the likelihood of resistance can be reduced [182]. Improved diagnostics also play a key role, enabling timely identification of fungal infections and facilitating targeted therapy [183]. The development and deployment of rapid and accurate diagnostic tools, including point-of-care options, PCR, next-generation sequencing, microfluidic chip technology, nanotechnology tools, new-generation biosensors, T 2 Candida, and artificial intelligence models are essential components of a comprehensive strategy to address fungal infections and AFR [21] [183] [184] [185].…”

Section: Strategies To Address Antifungal Resistancementioning

confidence: 99%

Global Burden of Fungal Infections and Antifungal Resistance from 1961 to 2024: Findings and Future Implications

Mudenda

2024

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Background: Antifungal resistance (AFR) is a global public health problem with devastating effects, especially among immunocompromised individuals. Addressing AFR requires a One Health approach including Antifungal Stewardship (AFS). This study aimed to comprehensively review global studies published on fungal infections and AFR and to recommend solutions to address this growing problem. Materials and Methods: This was a narrative review that was conducted using published papers on fungal infections, AFR, and AFS between January 1961 and March 2024. The literature was searched using PubMed, Google Scholar, Web of Science, and EMBASE. Results: This found that there has been an increase in fungal infections globally, especially among immunocompromised patients. Due to this increase in fungal infections, there has been a proportionate increase in the use of antifungal agents to prevent and treat fungal infections. This increased use of antifungal agents has worsened the problem of AFR contributing to increased morbidity and mortality. Globally, fungal infections have contributed to 150 million infections annually and 1.7 million deaths per year. By the year 2023, over 3.8 million people died from fungal infections. Addressing AFR remains a challenge because the treatment of antifungal-resistant infections is difficult. Finally, the treatment of fungal infections is a global challenge exacerbated by the limited number of antifungal agents to treat invasive fungal infections. Conclusion: The results of this study indicated that fungal infections and AFR are prevalent across humans, animals, agriculture, and the environment. Addressing this problem requires the provision of solutions such as improving the awareness of AFR, conducting further research on the discovery of new antifungal agents, and implementing AFS programs. If this global problem is not addressed, the morbidity and mortality associated with AFR will continue to rise in the future.How to cite this paper: Mudenda, S.

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The need for fast and accurate detection of dermatomycosis

Heckler¹,

Sabalza²,

Bojmehrani³

et al. 2023

Medical Mycology

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Dermatomycosis of the hair, skin or nails are one of the most common fungal infections worldwide. Beyond permanent damage to the affected area, the risk of severe dermatomycosis in immunocompromised people can be life-threatening. The potential risk of delayed or improper treatment highlights the need for a rapid and accurate diagnosis. However, with traditional methods of fungal diagnostics such as culture, a diagnosis can take several weeks. Alternative diagnostic technologies have been developed which allow for an appropriate and timely selection of an antifungal treatment, preventing nonspecific over-the-counter self-medication. Such techniques include molecular methods such as PCR, real-time PCR, DNA microarray, next-generation sequencing, in addition to matrix-assisted laser desorption ionization–time of flight (MALDI-TOF) mass spectrometry. Molecular methods can help close the “diagnostic gap” observed with traditional cultures and microscopy and allow for a rapid detection of dermatomycosis with increased sensitivity and specificity. In this review, advantages and disadvantages of traditional and molecular techniques are discussed, in addition to the importance of species-specific dermatophyte determination. Finally, we highlight the need for clinicians to adapt molecular techniques for the rapid and reliable detection of dermatomycosis infections and to reduce adverse events. Lay Abstract Dermatomycosis is one of the most common fungal infections worldwide. Traditional fungal diagnostics are limited and can take several weeks. Molecular techniques can detect dermatomycosis pathogens quickly and allow for species-specific identification which is important for treatment.

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Strategies to improve the diagnosis and clinical treatment of dermatophyte infections

Cited by 5 publications

References 78 publications

Superficial Zoonotic Mycoses in Humans Associated with Cats

Superficial Zoonotic Mycoses in Humans Associated with Cats

Global Burden of Fungal Infections and Antifungal Resistance from 1961 to 2024: Findings and Future Implications

The need for fast and accurate detection of dermatomycosis

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