"Strategies to improve the diagnosis and treatment of ischemia-reperfusion injury after lung transplantation"

Abstract

II. Introduction……………………………………………………………………………... a. Lung Transplantation and Current Limitations…………………………………….. b. Ischemia-Reperfusion Injury (IRI)………………………………………………….7 c. Ex vivo Lung Perfusion (EVLP)…………………………………………………… d. Imaging Methods to Diagnose Lung Injury………………………………………... e. Research Objectives………………………………………………………………... III. Lung Allograft Assessment with EVLP……………………………………………….. a. PROJECT #1. Donation After Circulatory Death Lungs Transplantable Up to Six Hours After Ex Vivo Lung Perfusion………………………………….... b. PROJECT #2. Ex Vivo Assessment of Donation after Circulatory Death Lungs Exposed to Increasing Warm Ischemia Time……………………………..... IV. Noninvasive Diagnosis of Lung IR Injury by SPECT Imaging……………………....