Strategies to improve the effect of mesenchymal stem cell therapy on inflammatory bowel disease

Abstract

Inflammatory bowel disease (IBD) includes Crohn’s disease and ulcerative colitis and is an idiopathic, chronic inflammatory disease of the colonic mucosa. The occurrence of IBD, causes irreversible damage to the colon and increases the risk of carcinoma. The routine clinical treatment of IBD includes drug treatment, endoscopic treatment and surgery. The vast majority of patients are treated with drugs and biological agents, but the complete cure of IBD is difficult. Mesenchymal stem cells (MSCs) have become a new type of cell therapy for the treatment of IBD due to their immunomodulatory and nutritional functions, which have been confirmed in many clinical trials. This review discusses some potential mechanisms of MSCs in the treatment of IBD, summarizes the experimental results, and provides new insights to enhance the therapeutic effects of MSCs in future applications.

A Comprehensive Exploration of Therapeutic Strategies in Inflammatory Bowel Diseases: Insights from Human and Animal Studies

“…The mechanism of action most likely differs between species and are affected by a variety of factors such as culture conditions or an inflammatory environment [33]. Adaptive immune cells (T and B lymphocytes) and innate immune cells (macrophages, dendritic cells, neutrophils, eosinophils, basophils, natural killer cells, and natural killer T cells) phenotype and function are both influenced by MSCs [77,[79][80][81]. MSCs' anti-inflammatory, immunomodulatory, and immunosuppressive capabilities serve as the foundation for their therapeutic use.…”

Stem Cell Therapy in Inflammatory Bowel Disease: A Review of Achievements and Challenges

“…These findings have shown us the potential application prospects and limitations of SC therapy for IBD. 16 , 96 However, further exploration and improvement of strategies are still necessary to lay the foundation for clinical research in this field.…”

“…Safety concerns associated with SC therapy include microcirculatory and coagulation dysfunction, immune rejection, and the risk of tumor formation. 96 , 114 …”

“…Safety concerns associated with SC therapy include microcirculatory and coagulation dysfunction, immune rejection, and the risk of tumor formation. 96,114 To enhance the use of SC therapy in treating IBD, several modifications have been proposed, such as changes to the culture conditions and cultivation methods for SCs, modification of SC contents and genetic genes, and extraction of SC derivatives. These strategies have the potential to optimize SC therapy and improve its efficacy and safety in treating IBD.…”

A Supportive Role of Mesenchymal Stem Cells on Insulin-Producing Langerhans Islets with a Specific Emphasis on The Secretome

“…MSCs have been shown to improve the medical conditions of a variety of immune-mediated diseases, including graft rejection, graft-versus-host disease, rheumatoid arthritis, systemic lupus erythromatosis, Crohn’s disease, colitis, osteoarthritis, multiple sclerosis, experimental autoimmune encephalomyelitis (EAE), and psoriasis [ 467 , 468 , 469 , 470 , 471 , 472 , 473 , 474 , 475 ]. Moreover, MSCs can promote wound healing and tissue regeneration [ 404 , 476 , 477 , 478 ].…”