Strategies to improve the implementation of intensive lifestyle interventions for obesity

Finn, Emily B.; Whang, Christine; Peng, Hong; Costa, Sergio A.; Callahan, Emily A.; Huang, Terry T.‐K.

doi:10.3389/fpubh.2023.1202545

Cited by 7 publications

(3 citation statements)

References 85 publications

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“…Die erste Versorgungslinie von Patient*innen mit Adipositas besteht im Allgemeinen aus einer Lebensstilintervention, die neben intensiver Ernährungs-und Bewegungstherapie auch eine Psychoedukation einschließt [64]. Durch diese Interventionen kann oft während des Behandlungszeitraums das Gewicht reduziert werden.…”

Section: Die Konservative Therapie Von Monogener Und Polygener Adipos...unclassified

Genetische Ursachen der Adipositas und ihre therapeutischen Implikationen

Rajcsanyi,

Schmidt,

Düerkop

et al. 2023

Adipositas - Ursachen, Folgeerkrankungen, Therapie

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ZusammenfassungAdipositas ist eine komplexe Störung, die von Umweltfaktoren und genetischen Varianten beeinflusst wird. Basierend auf den genetischen Grundlagen wird zwischen zwei Formen der Adipositas unterschieden. Die monogene (und syndromale) Adipositas ist selten und wird von Mutationen in jeweils einem Gen bedingt. Zur Manifestation einer extremen Adipositas mit Hyperphagie kommt es bereits in den ersten Lebensjahren. Abhängig vom betroffenen Gen können zudem weitere phänotypische Ausprägungen hinzukommen. Die polygene Adipositas dagegen ist weitaus häufiger. Ursächlich für diese Form ist eine Vielzahl von genetischen Varianten, die jeweils einen geringen, aber additiven Effekt auf das Körpergewicht haben. Frühzeitige genetische Diagnostik kann die vorliegende Form der Adipositas identifizieren und die Wahl einer geeigneten Therapieoption, ob Lebensstilintervention, bariatrische Chirurgie oder pharmakologische Behandlung, unterstützen. Wir stellen aktuelle Erkenntnisse der Forschung über die genetischen Ursachen der Adipositas dar. Zudem werden therapeutische und diagnostische Optionen, die teils auf genetischen Befunden basieren, beleuchtet.

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Section: Die Konservative Therapie Von Monogener Und Polygener Adipos...unclassified

Genetische Ursachen der Adipositas und ihre therapeutischen Implikationen

Rajcsanyi,

Schmidt,

Düerkop

et al. 2023

Adipositas - Ursachen, Folgeerkrankungen, Therapie

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“…Identifying key factors that facilitate or hinder implementation is beneficial, but many of the frameworks are static in that they do not explain the nature and dynamics of interrelationships among the identified determinants nor how those determinants might change over time. Many implementation science frameworks are top-down and deterministic ( 11 ), although some recent advances have been made to address community engagement in intervention implementation ( 12 ) and to guide adaptations during program implementation ( 13 ). Most implementation science frameworks, however, do not necessarily pinpoint the most promising focus areas or determinants, let alone how to intervene on them (i.e., how to select, design, tailor, and deliver implementation strategies) ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

Leveraging systems science and design thinking to advance implementation science: moving toward a solution-oriented paradigm

Huang,

Callahan,

Haines

et al. 2024

Front. Public Health

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Many public health challenges are characterized by complexity that reflects the dynamic systems in which they occur. Such systems involve multiple interdependent factors, actors, and sectors that influence health, and are a primary driver of challenges of insufficient implementation, sustainment, and scale of evidence-based public health interventions. Implementation science frameworks have been developed to help embed evidence-based interventions in diverse settings and identify key factors that facilitate or hinder implementation. These frameworks are largely static in that they do not explain the nature and dynamics of interrelationships among the identified determinants, nor how those determinants might change over time. Furthermore, most implementation science frameworks are top-down, deterministic, and linear, leaving critical gaps in understanding of both how to intervene on determinants of successful implementation and how to scale evidence-based solutions. Design thinking and systems science offer methods for transforming this problem-oriented paradigm into one that is solution-oriented. This article describes these two approaches and how they can be integrated into implementation science strategies to promote implementation, sustainment, and scaling of public health innovation, ultimately resulting in transformative systems changes that improve population health.

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“…In the context of burgeoning scientific and technological advancements, coupled with the burgeoning pharmaceutical sector, substantial progress has been achieved in the battle against obesity. Numerous strategies, encompassing calorie restriction, lifestyle management, pharmacotherapy, and bariatric surgery, have been suggested as interventions for combating obesity (10). Adipose tissue, traditionally seen as longterm energy storage, now plays a critical role in systemic metabolism through the secretion of proteins known as adipokines (11).…”

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confidence: 99%

Adipokines as a link between adipose tissue with inflammation and insulin resistance in cardiometabolic diseases

Fadaei

2023

ABI

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Obesity, a global health crisis, is associated with metabolic disorders and escalating healthcare burdens. This review explores the multifaceted dynamics of obesity, investigating the interplay of genetic, physiological, and environmental factors. Adipose tissue, traditionally regarded for energy storage, now emerges as a crucial contributor to systemic metabolism through the secretion of adipokines. Key adipokines, such as adiponectin, leptin, and the CTRPs superfamily (CTRP1, CTRP3, CTRP9, and CTRP12), are examined for their influence on inflammation, insulin resistance, and atherosclerosis. A critical understanding of the complex interplay between adipokines, inflammation, and insulin resistance is essential for comprehending the intricacies of metabolic dysfunction in obesity. Adipokines emerge as potential therapeutic targets to alleviate inflammation-related pathologies associated with obesity and related disorders. Ongoing research is pivotal to deepen the understanding of adipokine roles, paving the way for innovative therapeutic interventions. This review delves into the role of adipokines in cardiometabolic diseases, particularly emphasizing the intricate links between inflammation and insulin resistance in the context of obesity.

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Strategies to improve the implementation of intensive lifestyle interventions for obesity

Cited by 7 publications

References 85 publications

Genetische Ursachen der Adipositas und ihre therapeutischen Implikationen

Genetische Ursachen der Adipositas und ihre therapeutischen Implikationen

Leveraging systems science and design thinking to advance implementation science: moving toward a solution-oriented paradigm

Adipokines as a link between adipose tissue with inflammation and insulin resistance in cardiometabolic diseases

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