“…Exposure to an insufficient circulating level of P4 during the growth of the ovulatory follicle is one of the important factors that affect fertility in high producing animals. P4 has a negative feedback effect on LH secretion and it is believed that subluteal phase plasma P4 concentrations result in elevated LH pulse-frequency [20]. It has previously been suggested that low progesterone during early embryonic development may cause pregnancy failure and thereby reduce the pregnancy rate [33].…”