Strategies to Protect Dialysis Patients against Bisphenol A

Abstract

Bisphenol A (BPA), also known as 2,2,-bis(4-hydroxyphenyl) propane, is a common component of plastics worldwide. However, it has been shown to act as an endocrine disruptor with some hormonal functions. Furthermore, high levels of BPA have been related to the development of cardiovascular events and the activation of carcinogenesis pathways. Patients with chronic kidney disease (CKD) have higher serum concentrations of BPA due to their impaired renal function. This situation is aggravated in CKD patients requiring dialysis, because the BPA content of dialysis devices (such as, for example, the filters) is added to the lack of excretion. In addition to the development of BPA-free dialysis filters, some techniques can contribute to the reduction of BPA levels in these patients. The aim of this review is to illustrate the impact of BPA on dialysis patients and suggest some strategies to reduce its inherent risks.

Bisphenol A and Bisphenol S in Hemodialyzers

“…Like other protein-bound uremic toxins, enhanced removal using high-flux and medium cut-off dialyzers in combination with hemodiafiltration reduce bisphenol levels in dialysis patients [ 17 ]. Other strategies can be implemented to reduce the risks of bisphenol levels in these patients [ 18 , 19 ].…”