Strategies to Refine Gastric Stimulation and Pacing Protocols: Experimental and Modeling Approaches

Cheng, Leo K.; Nagahawatte, Nipuni D; Avci, Recep; Du, Peng; Li, Zhong‐Ming; Paskaranandavadivel, Niranchan

doi:10.3389/fnins.2021.645472

Cited by 32 publications

(21 citation statements)

References 198 publications

(229 reference statements)

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“…The circumferential arrangement of the circular muscle bundles, and the small bands of muscle that connect adjacent bundles, are consistent with rapid circumferential conduction of excitation and slower conduction orthoganol to the bundles. The quantitative data that has been obtained in this study is expected to enhance modelling of gastric function (Cheng et al, 2021).…”

Section: Con Clus Ionsmentioning

confidence: 82%

“…

A range of disorders of stomach movements affects patients, including gastroparesis, functional dyspepsia, reflux, pyloric stenosis and rapid gastric emptying (Cheng et al, 2021;Keller et al, 2018;Tack & Pandolfino, 2018). These disorders commonly have downstream or associated symptoms, including early post-prandial fullness and satiety, nausea, vomiting, regurgitation, bloating, upper abdominal distension, abdominal pain and weight loss.

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mentioning

confidence: 99%

“…gastric movement depends on generation of electrical rhythmicity and electrical conduction, there has been considerable effort made to analyse and model the electrical events on which the movements of the stomach depend (Cheng et al, 2021;Du et al, 2013;Sanders & Publicover, 1989). The conduction of electrical events in the stomach muscle, and the directions and strengths of forces generated when the muscle is excited, depend on the organisation of the musculature.…”

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confidence: 99%

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Organisation of the musculature of the rat stomach

et al. 2021

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A range of disorders of stomach movements affects patients, including gastroparesis, functional dyspepsia, reflux, pyloric stenosis and rapid gastric emptying (Cheng et al., 2021;Keller et al., 2018;Tack & Pandolfino, 2018). These disorders commonly have downstream or associated symptoms, including early post-prandial fullness and satiety, nausea, vomiting, regurgitation, bloating, upper abdominal distension, abdominal pain and weight loss. Because these conditions are common and poorly treated and because co-ordination of

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Section: Con Clus Ionsmentioning

confidence: 82%

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confidence: 99%

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Organisation of the musculature of the rat stomach

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“…The GI myoelectric abnormalities observed in the models of gastroparesis, intractable nausea and vomiting, and intestinal obstruction provide a theoretical basis for the development of GI electrical stimulation (GIES) therapy[ 38 , 44 ]. According to the location of electrical stimulation, GIES can be divided into inhibitory electrical stimulation and excitatory electrical stimulation[ 45 ]. Inhibitory electrical stimulation can inhibit the contractile movement of the normal GI tract by placing the electrode near the tail end of the GI tract to send stimulation signals, forcing GI myoelectric activity and movement to reverse propagation[ 46 , 47 ].…”

Section: Emgmentioning

confidence: 99%

Clinical application and research progress of extracellular slow wave recording in the gastrointestinal tract

Ding¹,

Guo²,

Cui³

et al. 2022

WJGS

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The physiological function of the gastrointestinal (GI) tract is based on the slow wave generated and transmitted by the interstitial cells of Cajal. Extracellular myoelectric recording techniques are often used to record the characteristics and propagation of slow wave and analyze the models of slow wave transmission under physiological and pathological conditions to further explore the mechanism of GI dysfunction. This article reviews the application and research progress of electromyography, bioelectromagnetic technology, and high-resolution mapping in animal and clinical experiments, summarizes the clinical application of GI electrical stimulation therapy, and reviews the electrophysiological research in the biliary system.

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“…The use of multichannel suction electrode array will help in dysrhythmia analysis and assessment of therapeutics, by enabling the ability to monitor these electrophysiology metrics in high-resolution. For example, during pacing or ablation strategies,49,50 the slow wave recovery phase could be useful to determine the accurate timing of impulses or the precise location for ablation. Contact surface electrodes have been used to record slow waves from gastric mucosal surface 51.…”

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High‐resolution in vivo monophasic gastric slow waves to quantify activation and recovery profiles

Han

Cheng

Paskaranandavadivel

2022

Neurogastroenterology Motil

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Background: Gastric bio-electrical slow waves are, in part, responsible for coordinating motility. Spatial dynamics about the recovery phase of slow wave recordings have not been thoroughly investigated due to the lack of suitable experimental techniques. Methods:A high-resolution multi-channel suction electrode array was developed and applied in pigs to acquire monophasic gastric slow waves. Signal characteristics were verified against biphasic slow waves recorded by conventional surface contact electrode arrays. Monophasic slow wave events were categorized into two groups based on their morphological characteristics, after which their amplitudes, activation to recovery intervals, and gradients were quantified and compared. Coverage of activation and recovery maps for both electrode types were calculated and compared.Key Results: Monophasic slow waves had a more pronounced recovery phase with a higher gradient than biphasic slow waves (0.5 ± 0.1 vs. 0.3 ± 0.1 mV•s −1 ). Between the 2 groups of monophasic slow waves, there was a significant difference in amplitude (1.8 ± 0.5 vs. 1.1 ± 0.2 mV), activation time gradient (0.8 ± 0.2 vs. 0.3 ± 0.1 mV•s −1 ), and recovery time gradient (0.5 ± 0.1 vs. 0.3 ± 0.1 mV•s −1 ). For the suction and conventional contact electrode arrays, the recovery maps had reduced coverage compared to the activation maps (4 ± 6% and 43 ± 11%, respectively). Conclusions and Inferences:A novel high-resolution multi-channel suction electrode array was developed and applied in vivo to record monophasic gastric slow waves.Slow wave recovery phase analysis could be performed more efficiently on monophasic signals compared with biphasic signals, due to the more identifiable recovery phases.

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Strategies to Refine Gastric Stimulation and Pacing Protocols: Experimental and Modeling Approaches

Cited by 32 publications

References 198 publications

Organisation of the musculature of the rat stomach

Organisation of the musculature of the rat stomach

Clinical application and research progress of extracellular slow wave recording in the gastrointestinal tract

High‐resolution in vivo monophasic gastric slow waves to quantify activation and recovery profiles

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