Strategies Toward the Catalyst-Free α-C–H Functionalizations of Tertiary Amines

Catalyst-free photoarylation reactions promoted by visible light

“…Using visible light as a promoter eliminates the need for toxic and expensive catalysts, reducing costs and making the process more sustainable. 26 Furthermore, photocatalyzed arylation reactions have been exhaustively explored in review papers over the past decade, whilst catalyst-free arylations have been neglected in this concern, as can be seen by the more than 79 review papers on photocatalyzed arylations vs. only 2 reviews 27,28 on catalyst-free arylations found on the Web of Science database up to the present moment. Thus, we believe it is relevant to provide a collection of the latest updates in this ascending field.…”

α-Acyloxylation of Ketones/Cyclic Ethers Mediated by Hypervalent Iodine(III) Reagents as Oxidants and Nucleophilic Sources

“…The trend in synthetic chemistry is to develop easy-to-handle, simple, and green reactions, particularly those that are free of metal . Hypervalent iodine compounds, functioning like metal catalysts, , have been widely utilized to initiate various chemical reactions, including acetoxylation of carbonyls and cyclic ethers , as well as tetrahydrofuranylation of alcohols .…”