Strategies towards the Synthesis of 2‐Ketoaryl Azole Derivatives using C‐H Functionalization Approach and 1,2‐Bis‐Nucleophile Precursors

Abstract

A spectrum of compounds attached to 2‐keto aryl azole moieties are found as pivotal building blocks in medicinal chemistry and drug discovery. This is why, the collection of novel methods have been described for the synthesis of these compounds, which are of great significance among organic chemists interested towards the development of new synthetic methods in the fields of natural products, bioactive molecules and materials sciences. This review presents the important breakthrough achieved during last decade towards improvement of approaches for the synthesis of these molecules.

Biomedical applications of selective metal complexes of indole, benzimidazole, benzothiazole and benzoxazole: A review (From 2015 to 2022)

“…( Al-Saidi and Khan, 2022a , Al-Saidi and Khan, 2022b , Aljaar et al, 2019 , Alrooqi et al, 2022 , Gemili et al, 2019 , Gul et al, 2022 , Kabi et al, 2022b , Khan et al, 2020 , Khan et al, 2022a , Khan et al, 2022b , Mohammad Abu-Taweel et al, 2022 , Muhammad et al, 2022 ). These compounds have excellent biological applications such as anti-ulcerogenic, anti-cancer, antihypertensive, antifungal, anti-inflammatory, antitubercular, antiparasitic, anti-obesity, antimalarial, antiglycation, antiviral potency, antineuropathic, analgesic antioxidant, antihistaminic, and antibacterial potentials ( Aljaar et al, 2023 , Aljaar et al, 2015 , Aljaar et al, 2013 , Gujjarappa et al, 2022 , Gujjarappa et al, 2020 , Kabi et al, 2022a , Kaldhi et al, 2019 , Shafiei et al, 2020 , Vodnala et al, 2018 ). Indole nucleus ( Fig.…”