Strategy to Decrease the Risk of Adverse Effects of Fragrance Ingredients in Cosmetic Products

A Comparative Human Health Risk Assessment ofp-Dichlorobenzene-Based Toilet Rimblock Products Versus Fragrance/Surfactant-Based Alternatives

“…Only 0.2% isoeugenol is recommended in products without skin contact such as toilet block products (IFRA, 2005). Kathon (a mixture of methylchloroisothiazolinone and methylisothiazolinone), one of the most potent sensitizers, was reported to induce an allergic response at concentrations between 10 and 20 ppm (Jansson & Loden, 2001). While neither isoeugenol nor Kathon is present in either of the two alternative rimblock fragrance mixtures, these values provide support that the fragrance compounds in the two alternative rimblock products are expected to be present in indoor air at concentrations that are too low to induce an allergic respiratory response in a healthy individual.…”

“…However, IFRA has set limits for several fragrance components based on sensitization concerns. The toughest of these was set for isoeugenol (Jansson & Loden, 2001). Only 0.2% isoeugenol is recommended in products without skin contact such as toilet block products (IFRA, 2005).…”