Strategy to fight against malnutrition in chronic patients with complex health needs

Burgos, R.; Joaquín, Clara; Blay, Carles; Ledesma, Albert; Figueiras, Guadalupe; Pérez-Portabella, C.; Granados, Antonio; Gómez, M. A.; González, Asunción; Sarquella, Esther; Amil, Paloma; Crusellas, Cristina Vaqué

doi:10.5334/ijic.2709

Cited by 4 publications

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“…Poor nutritional status and malnutrition in the elderly population are important areas of concern, associated with an increased financial cost burden [ 43 ] and reduced quality of life [ 44 ]. Drug classes with potentially significant drug–nutrient interactions include: antihypertensives by causing zinc deficiency (thiazide diuretics, angiotensin receptor blockers, angiotensin converting enzyme inhibitors and potassium-sparing diuretics); acetylcholinesterase inhibitors; proton pump inhibitors and metformin by causing vitamin B12 deficiency; HMG-Co reductase inhibitors (statins) by causing reductions in CoQ10, a-tocopherol, b-carotene and lycopene and long-term, high-dose aspirin by causing vitamin C deficiency [ 45 ].…”

Section: Polypharmacotherapymentioning

confidence: 99%

Pharmacological Interactions in the Elderly

et al. 2020

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Pharmacological therapy in the elderly is particularly complicated and challenging. Due to coexistence of three main predisposing factors (advanced age, multiple morbidity and polypharmacotherapy), this group of patients is prone to occurrence of drug interactions and adverse effects of incorrect drug combinations. Since many years patient safety during the treatment process has been one of key elements for proper functioning of healthcare systems around the world, thus different preventive measures have been undertaken in order to counteract factors adversely affecting the therapeutic effect. One of the avoidable medical errors is pharmacological interactions. According to estimates, one in six elderly patients may be at risk of a significant drug interaction. Hence the knowledge about mechanisms and causes of drug interactions in the elderly, as well as consequences of their occurrence are crucial for planning the process of pharmacotherapy. For the purpose of pharmacovigilance, a review of available methods and tools gives an insight into possible ways of preventing drug interactions. Additionally, recognizing the actual scale of this phenomenon in geriatric population around the world emphasizes the importance of a joint effort among medical community to improve quality of pharmacotherapy.

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Section: Polypharmacotherapymentioning

confidence: 99%

Pharmacological Interactions in the Elderly

et al. 2020

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“…As increasing age is generally associated with a greater burden of disease, it is associated with increased and often overused medication. A cohort study emphasized that the most important social and health determinants affecting disease-related malnutrition are living alone, polypharmacy and dysphagia, and that these strategies should be focused on to improve patient care 21 . In a large cohort of more than 1300 participants, it was stated that 51% of older adults with T2DM, who participated in the study, were using five or more drugs, and malnutrition and malnutrition risk were twice higher in these patients.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Relationship Between Polypharmacy and Malnutrition in Diabetic Elderly

Yakaryılmaz¹,

Eraydın²

2022

NKTD

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Aim: Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases in older adults. With advancing age, polypharmacy and proteinenergy malnutrition associated with chronic diseases can be seen frequently in T2DM patients due to metabolic causes and may adversely affect the prognosis. In this study, it was aimed to evaluate the relationship between polypharmacy and malnutrition in T2DM patients.Materials and Methods: Three hundred and twenty-one patients aged 65 years and over, diagnosed with T2DM and receiving oral anti-diabetic drug therapy, who applied to the Internal Medicine and Geriatrics outpatient clinic between February and November 2021, were included in the study. The data of the patients were obtained retrospectively from their medical files. The use of 5 or more drugs was considered as polypharmacy. Mini Nutritional Assessment-short form (MNA-SF) was used for nutritional status assessment. Results:The median number of concomitant medications used in patients followed up with the diagnosis of T2DM was 5. Polypharmacy was found in 209 (65.1%) patients, and severe polypharmacy was found in 21 (6.5%) patients. Malnutrition was found in 43 (20.6%) patients with polypharmacy, while 17 (80.1%) of 21 patients with severe polypharmacy had malnutrition. A positive correlation was found between the number of drugs and HbA1c, and a negative correlation with the MNA-SF score (r=0.792, p<0.001, r=-0.317, p<0.001, respectively). According to the logistic regression analysis, the presence of HbA1c and polypharmacy were found to be effective factors in the development of malnutrition (p=0.009, p=0.002). Conclusion:Current findings show that polypharmacy is quite common in elderly T2DM patients and often accompanies malnutrition. It is important to review the drugs used in each visit and to evaluate malnutrition that may be related to newly started or currently used drugs so that intertwined polypharmacy and malnutrition are not overlooked in elderly patients.

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“…diseases and weakness [16,17,18], multiple medications [19,20,21,22,23], malnutrition [24,25,26], falls [27], gradually became hot research topics for scintists studying the course of COVID-19 [28,29,30,31,32]. In addition, multimorbidity further complicates disease treatment and rehabilitation and increases the risk of mental and physical complications [33,34].…”

Section: огляди літератури / Literature Reviewsmentioning

confidence: 99%

The Features of Comorbidity Among Elderly and Senile Patients

Trybrat¹,

Шуть²,

Ivanytska³

et al. 2023

VPBM

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A -Work concept and design, B -Data collection and analysis, C -Responsibility for statistical analysis, D -Writing the article, E -Critical review, F -Final approval of the article / A -концепція роботи та дизайн, В -збір та аналіз даних, С -відповідальність за статичний аналіз, D -написання статті, Е -критичний огляд, F -остаточне затвердження статті.

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Strategy to fight against malnutrition in chronic patients with complex health needs

Cited by 4 publications

References 0 publications

Pharmacological Interactions in the Elderly

Pharmacological Interactions in the Elderly

Evaluation of the Relationship Between Polypharmacy and Malnutrition in Diabetic Elderly

The Features of Comorbidity Among Elderly and Senile Patients

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