Mississippian Meramec deposits and reservoirs in the Sooner Trend in the Anadarko (Basin) in Canadian and Kingfisher counties (STACK) play of central Oklahoma are comprised of silty limestones, calcareous sandstones, argillaceous-calcareous siltstones, argillaceous siltstones, and mudstones. We have used core-derived X-ray fluorescence (XRF) data and established environmental proxies to evaluate the occurrence of specific elements (Al, K, Ti, Zr, Sr, Ca, and Si) and to illustrate their stratigraphic variability. For the Mississippian Meramec, six indicator elements or element ratios serve as proxies for clay (Al and K), detrital sediment (Ti and Zr), carbonate deposits (Sr and Ca), calcite cement (Sr/Ca), and biogenic and continentally derived quartz (Si/Ti and Si/Al). We used an unsupervised K-means classification to cluster elemental data from which we interpret three chemofacies: (1) calcareous sandstone, (2) argillaceous-calcareous siltstone, and (3) detrital mudstone. We used a random forest approach to relate core-derived chemofacies to well logs and classify chemofacies in noncored wells with an accuracy of up to 83% based on blind test results. We integrated core-derived XRF, conventional well logs, and chemofacies logs to produce a dip-oriented cross-sectional chemofacies model that trends from the northwest to the southeast across the southern STACK trend. Meramec chemofacies distributions reflect parasequence stacking patterns. The stratigraphic variability of chemofacies indicates an upward increase of argillaceous detrital mudstone from parasequences 1 to 3. Parasequence 3 is capped by a maximum flooding surface. From parasequences 4 to 5, an increase in argillaceous-calcareous siltstone and calcareous sandstone reflects the progradational stacking. Porosity is relatively low in calcareous sandstones primarily due to calcite cement. Water saturation is high in argillaceous-calcareous siltstone, moderate in calcareous sandstone, and low in detrital mudstone. Within the Meramec, biogenic quartz is associated with drilling issues, specifically frequent bit trips due to its hardness. Interpreted biogenic quartz from element profiles corresponds to the calcareous sandstone chemofacies, which can be estimated from triple-combo well logs and can be mapped. Effective porosity and water saturation models reflect the stratigraphic variability of chemofacies and rock types and can be predicted within the defined chemostratigraphic framework. Understanding the spatial variability of effective porosity and water saturation is important for reservoir development planning.