Stratum corneum lipid profile and maturation pattern of corneocytes in the outermost layer of fresh scars: the presence of immature corneocytes plays a much more important role in the barrier dysfunction than do changes in intercellular lipids

Kunii, Tomonori; Hirao, Tetsuji; Kikuchi, Kenji; Tagami, Hachiro

doi:10.1046/j.1365-2133.2003.05545.x

Cited by 48 publications

(43 citation statements)

References 31 publications

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“…The CE, an essential structure for barrier function, consists of involucrin, loricrin, small proline-rich proteins and other proteins covalently cross-linked by epidermal transglutaminases (TGases) [138]. Besides, the maturation of CE in the SC is also important in proper barrier formation [139]. On the other hand, the tight junction proteins in mammalian epidermis also contribute to the various skin functions including barrier formation [140].…”

Section: Mechanisms Underlying Skin Barrier Improvementmentioning

confidence: 99%

Potential Applications of Phyto-Derived Ceramides in Improving Epidermal Barrier Function

Tessema

Gebre‐Mariam

Neubert

et al. 2017

Skin Pharmacol Physiol

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The outer most layer of the skin, the stratum corneum, consists of corneocytes which are coated by a cornified envelope and embedded in a lipid matrix of ordered lamellar structure. It is responsible for the skin barrier function. Ceramides (CERs) are the backbone of the intercellular lipid membranes. Skin diseases such as atopic dermatitis and psoriasis and aged skin are characterized by dysfunctional skin barrier and dryness which are associated with reduced levels of CERs. Previously, the effectiveness of supplementation of synthetic and animal-based CERs in replenishing the depleted natural skin CERs and restoring the skin barrier function have been investigated. Recently, however, the barrier function improving effect of plant-derived CERs has attracted much attention. Phyto-derived CERs (phytoCERs) are preferable due to their assumed higher safety as they are mostly isolated from dietary sources. The beneficial effects of phytoCER-based oral dietary supplements for skin hydration and skin barrier reinforcement have been indicated in several studies involving animal models as well as human subjects. Ingestible dietary supplements containing phytoCERs are also widely available on the market. Nonetheless, little effort has been made to investigate the potential cosmetic applications of topically administered phytoCERs. Therefore, summarizing the foregoing investigations and identifying the gap in the scientific data on plant-derived CERs intended for skin-health benefits are of paramount importance. In this review, an attempt is made to synthesize the information available in the literature regarding the effects of phytoCER-based oral dietary supplements on skin hydration and barrier function with the underlying mechanisms.

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Section: Mechanisms Underlying Skin Barrier Improvementmentioning

confidence: 99%

Potential Applications of Phyto-Derived Ceramides in Improving Epidermal Barrier Function

Tessema

Gebre‐Mariam

Neubert

et al. 2017

Skin Pharmacol Physiol

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show abstract

“…Maturation of CE is essential for a proper barrier function, 10) and it is known that a decrease of ceramide causes impairment of the barrier function in human skin.…”

mentioning

confidence: 99%

Orally Administered Glucosylceramide Improves the Skin Barrier Function by Upregulating Genes Associated with the Tight Junction and Cornified Envelope Formation

Ideta¹,

Sakuta²,

Nakano³

et al. 2011

Bioscience, Biotechnology, and Biochemistry

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“…As shown by Marks, the smaller the corneocyte the greater the TEWL [98]. In addition, recovery of barrier function after scarring is also very much dependent on changes in corneocyte size and maturation and appears to be less so for lipid changes but more characterization is needed [99]. As will be seen later retention of immature fragile envelopes occurs in barrier-compromised conditions such as dry skin.…”

Section: Corneocyte Envelope Maturationmentioning

confidence: 94%

The Stratum Corneum and Aging

Rawlings

2010

Textbook of Aging Skin

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Stratum corneum lipid profile and maturation pattern of corneocytes in the outermost layer of fresh scars: the presence of immature corneocytes plays a much more important role in the barrier dysfunction than do changes in intercellular lipids

Abstract: These results suggest that the SC barrier dysfunction of the fresh scars is attributable to the presence of immature corneocytes with a less hydrophobic CE, rather than to the changes in SC lipid composition.

Cited by 48 publications

References 31 publications

Potential Applications of Phyto-Derived Ceramides in Improving Epidermal Barrier Function

Potential Applications of Phyto-Derived Ceramides in Improving Epidermal Barrier Function

Orally Administered Glucosylceramide Improves the Skin Barrier Function by Upregulating Genes Associated with the Tight Junction and Cornified Envelope Formation

The Stratum Corneum and Aging

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