Strawberries on the Brain—Intracranial Capillary Hemangioma: Two Case Reports and Systematic Literature Review in Children and Adults

Surgical management of intracranial capillary hemangiomas in children: report of 2 cases

“…The response of cutaneous capillary hemangiomas in infancy to exogenous steroids is a wellrecognized treatment to avoid surgery or to shrink lesions before undertaking surgery. 10 Steroid receptor positivity was seen in 3 of 10 lesions involving the brain or spinal cord. 2 Whether steroid receptor presence correlates with a therapeutic response to glucocorticoids is not known.…”

Giant cranial and cerebellar hemangioma treated with propranolol

“…Most infantile and congenital hemangiomas seem to follow a benign course and spontaneously arrest or regress; however, some are at risk for developing complications and warrant treatment [8,13]. Treatment options for hemangiomas include medical options, surgical options, or careful follow-up [5,8].…”

“…Treatment options for hemangiomas include medical options, surgical options, or careful follow-up [5,8]. Recent studies suggest the effectiveness of β-adrenergic receptor antagonists (β-blockers), such as propranolol, in treating infantile hemangiomas as well as other vascular lesions which express β 2 -adrenergic receptors [4,7].…”

A case of giant fetal intracranial capillary hemangioma cured with propranolol

“…Although angiography is rarely performed, such studies of these tumors reveal enlarged arterial feeders and intense contrast staining, with pooling of the contrast medium within tumoral vascular spaces. 2,13,21,23 Doppler US of intracranial capillary hemangiomas indicates numerous intralesional and perilesional vessels, with a high-peak arterial Doppler shift. 23 The aforementioned imaging findings are not exclusive to intracranial capillary hemangiomas; in fact, these tumors must primarily be differentiated from meningiomas, hemangiopericytomas, and hemangioblastomas.…”

“…Surgery was performed in certain cases, whereas other cases involved clinical observation and/or treatment with steroids, thalidomide, bevacizumab, and/or temozolomide. 3,4,13,25 A different scenario is applicable for cutaneous hemangiomas. 12,15,24 In particular, for such tumors, propranolol has been the first-line treatment since Léauté-Labrèze et al 10 published a case series in 2008 that described severe infantile hemangiomas treated with this beta-blocker with excellent outcomes.…”