sTREM-1 predicts intensive care unit and 28-day mortality in cancer patients with severe sepsis and septic shock

Ravetti, Cecilia Gómez; Moura, Anselmo Dornas; Vieira, Érica Leandro Marciano; Pedroso, Ênio Roberto Pietra; Teixeira, Antônio Lúcio

doi:10.1016/j.jcrc.2014.12.002

Cited by 22 publications

(12 citation statements)

References 40 publications

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“…Similarly, AUC of 0.68 (95% CI 0.58–0.78) for sTREM-1 for predicting hospital mortality was observed by Latour-Perez et al (2010). The serum concentration of sTREM-1, but not IL-6 or IL-8, also predicted the ICU mortality and 28-day mortality in cancer patients with severe sepsis and septic shock (Ravetti et al 2015). …”

Section: Discussionmentioning

confidence: 99%

Soluble TREM-1 Serum Level can Early Predict Mortality of Patients with Sepsis, Severe Sepsis and Septic Shock

Jedynak

Siemiątkowski

Mroczko

et al. 2017

Arch. Immunol. Ther. Exp.

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Early prognostic prediction of sepsis is essential in adjusting therapeutic protocols to prevent deterioration and reduce mortality. We compared the predictive value of the serum concentration of the soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) for 28-day mortality and for the development of severe sepsis or septic shock on the third day with the levels of interleukin (IL)-6, C-reactive protein (CRP) and procalcitonin (PCT). The study was conducted on 85 patients with sepsis. sTREM-1, CRP, PCT and IL-6 concentrations were measured upon study inclusion (day 0) and on days 1, 2, 3 and 5. APACHE II, SAPS II and SOFA scores were analyzed. The sTREM-1 levels (pg/ml) were higher in non-survivors than in survivors at admission (773 vs. 391, p < 0.001) and on days 1, 2, 3 and 5. In predicting the development of severe sepsis, the highest AUCs were found for PCT (0.744, 95% CI 0.638–0.85) and sTREM-1 (0.664, 95% CI 0.55–0.778); and in septic shock prediction, for PCT (0.766, 95% CI 0.665–0.867) and IL-6 (0.707, 95% CI 0.595–0.819). sTREM-1 positively correlated with APACHE II, SAPS II and SOFA scores. At inclusion, significant AUC for predicting 28-day mortality was 0.772 for the sTREM-1 (95% CI 0.672–0.871), 0.858 for APACHE II (95% CI 0.768–0.948), 0.847 for SAPS II (95% CI 0.733–0.96), 0.806 for SOFA score (95% CI 0.698–0.915). sTREM-1 can early predict the 28-day sepsis mortality, although its effectiveness is lower in comparison with clinical severity scores.Electronic supplementary materialThe online version of this article (10.1007/s00005-017-0499-x) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Soluble TREM-1 Serum Level can Early Predict Mortality of Patients with Sepsis, Severe Sepsis and Septic Shock

Jedynak

Siemiątkowski

Mroczko

et al. 2017

Arch. Immunol. Ther. Exp.

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“…Similar findings were obtained recently in a small cohort of cancer patients. Indeed, Ravetti et al showed that levels of sTREM-1 over time were higher in survivors than in non-survivors [ 17 ]. This may be subsequent to the dual significance of plasma levels of sTREM-1.…”

Section: Discussionmentioning

confidence: 99%

Significance of soluble triggering receptor expressed on myeloid cells-1 elevation in patients admitted to the intensive care unit with sepsis

Charles

Bastie²,

Massin

et al. 2016

BMC Infect Dis

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BackgroundAmong septic patients admitted to the intensive care unit (ICU), early recognition of those with the highest risk of death is of paramount importance. Since clinical judgment is sometimes uncertain biomarkers could provide additional information likely to guide critical illness management. We evaluated the prognostic value of soluble Triggering Receptor Expressed by Myeloid cells 1 (sTREM-1), procalcitonin (PCT) and leucocyte surface expression of CD64.MethodsThis was a prospective cohort study, which included 190 septic patient admitted to the ICU in two hospitals. Blood samples for biomarker measurements were obtained upon admission and thereafter. The Simplified Acute Physiology Score (SAPS) II and the Sequential Organ Failure Assessment (SOFA) score were calculated. The primary outcome was all-cause death in the ICU.ResultsThe mortality rate reached 25.8 %. The best predictive value of the three biomarkers was obtained with baseline sTREM-1, although clinical scores outperformed this. Accuracy was greater in patients without prior exposure to antibiotics and in those with proven bacterial infection. Adding sTREM-1 levels to SAPS II increased its specificity to 98 %. The soluble TREM-1 level, core temperature and SAPS II value were the only independent predictors of death after adjustment for potential confounders. A decrease in sTREM-1 with time was also more pronounced in survivors than in non-survivors.ConclusionssTREM-1 was found to be the best prognostic biomarker among those tested. Both baseline values and variations with time seemed relevant. Although SAPS II outperformed sTREM-1 regarding the prediction of ICU survival, the biomarker could provide additional information.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-016-1893-4) contains supplementary material, which is available to authorized users.

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“…Plasma levels of sTREM‐1 at admission could also be used as a marker to identify patients with a poor prognosis as the sTREM‐1 levels in non‐survivors with severe sepsis who even received early goal‐directed therapy after admission remained high until death . In cancer patients with sepsis who might display a more complexed immune profile, the plasma level of sTREM‐1 is still a good predictor of 28‐day mortality . When compared with other biomarkers such as PCT and CRP in predicting survival of patients with septic shock, sTREM‐1 was found to be beneficial .…”

Section: Alteration Of Neutrophil Function In Sepsismentioning

confidence: 99%

Neutrophil dysregulation during sepsis: an overview and update

Shen

Cao

Jiang

et al. 2017

J Cellular Molecular Medi

242

203

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Sepsis remains a leading cause of death worldwide, despite advances in critical care, and understanding of the pathophysiology and treatment strategies. No specific therapy or drugs are available for sepsis. Neutrophils play a critical role in controlling infection under normal conditions, and it is suggested that their migration and antimicrobial activity are impaired during sepsis which contribute to the dysregulation of immune responses. Recent studies further demonstrated that interruption or reversal of the impaired migration and antimicrobial function of neutrophils improves the outcome of sepsis in animal models. In this review, we provide an overview of the associated mediators and signal pathways involved which govern the survival, migration and antimicrobial function of neutrophils in sepsis, and discuss the potential of neutrophils as a target to specifically diagnose and/or predict the outcome of sepsis.

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sTREM-1 predicts intensive care unit and 28-day mortality in cancer patients with severe sepsis and septic shock

Cited by 22 publications

References 40 publications

Soluble TREM-1 Serum Level can Early Predict Mortality of Patients with Sepsis, Severe Sepsis and Septic Shock

Soluble TREM-1 Serum Level can Early Predict Mortality of Patients with Sepsis, Severe Sepsis and Septic Shock

Significance of soluble triggering receptor expressed on myeloid cells-1 elevation in patients admitted to the intensive care unit with sepsis

Neutrophil dysregulation during sepsis: an overview and update

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