Cold-formed steel members are usually used as purlins in buildings to support roof cladding and thus they can be treated as the restrained beams fully or partially in its lateral and torsional directions. However, when these beams are subjected to wind suction loading, their free flange is in compression, which may cause web-flange distortional buckling (WFDB). This paper presents an analytical study on the WFDB of zed-section purlins when subjected to uplift bending. A simplified model is proposed to describe the WFDB of partially restrained purlins, from which the formula for calculating the critical stress of the WFDB is derived. The present model is validated by the results obtained from the finite strip analysis.