Purpose. To study the systemic influence of the high levels of low-cycle alternating loading and other factors on the strength, crack resistance and deformability of girder reinforced concrete structures and to improve engineering methodology of their calculation based on the deformation method, taking into account these and other factors. Methodology. Experimental researches are performed according to the theory of planning by means of the threelevel four-factor plan of Boks B4 for the studying of these and other questions. Specimens are rectangular reinforced concrete beams with the sizes 200×100 mm, with the length of 1975 mm, reinforced with two flat welded frames with symmetric longitudinal bottom and top reinforcement 2 ø 14А500С and transverce reinforcement 2ø3, 4, 5 ВрI with the relative shear span a / h0 1, 2, 3, made from heavy concrete of the grades С 16/20 (В20), С 30/35 (В35), С 40 / 50 (В50), and tested by low-cycle alternating loading of different levels. Findings. The results of the tests of these specimens-beams, produced at the average values of constructive factors and tested on the action of low-cycle alternating loading with the levels 0,5 ; 0,65 ; 0,8 are considered in this paper.Originality. New experimental data on the strength, crack resistance and deformability of specimens-beams, reached the end of their load-bearing capacity by means of low-cycle alternating loading of high levels were first obtained. Fulfillment of the planned experimental and theoretical researches in full will give the opportunity to assessthe systemic impact of structural factors and factors of external influence on these parameters in particular, and in interaction, improve the methodology for strength calculation both inclined and normal sections of the span elements, as well as their crack resistance and deformability on the basis of the deformation model, to develop proposalsfor improving the current regulatory methods for calculating of their bearing capacity. Practical value. The results will be used in the educational process in university of building profile, the design of span reinforced concrete structures that are affected by low-cycle alternating loads with high levels, which will increase their reliability and durability, make informed decisions on rational using of materials.