Strength of cancellous bone trabecular tissue from normal, ovariectomized and drug-treated rats over the course of ageing

McNamara, Laoise M.; Ederveen, A. G. H.; Lyons, Christopher; Price, Christopher; Schaffler, Mitchell B.; Weinans, Harrie; Prendergast, Patrick J.

doi:10.1016/j.bone.2006.02.070

Cited by 75 publications

(87 citation statements)

References 49 publications

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“…details regarding stress transfer between constituents in various mineral-collagen arrangements and its effect of macroscopic behaviour), see Figures 3(c) and 4. We propose that the approach developed in this study could be applied to further understand the large discrepancies in reports of mechanical behaviour of bone tissue between different experimental test methods (Runkle and Pugh 1975;Townsend et al 1975;Mente and Lewis 1989;Ryan and Williams 1989;Choi et al 1990;Rho et al 1993;Samelin et al 1996;Rho et al 1997;Rho et al 1998;Rho et al 1999;Zysset et al 1999;Hoffler et al 2000;Ferguson et al 2003;McNamara et al 2006a;Ozcivici et al 2008;McNamara 2011), but also to decipher the impact of changes in tissue composition or structure during disease. From the results presented here, it is clear that a major contributor to this large range of experimentally reported stiffness values is the MVF (Figures 3 and 5).…”

Section: Discussionmentioning

confidence: 99%

“…Mechanical testing of trabecular and cortical bone tissue has been carried out using 3/4-point bending (Choi et al 1990), buckling (Runkle and Pugh 1975;Townsend et al 1975), cantilever beam tests (Mente and Lewis 1989), micro-tensile testing (Ryan and Williams 1989;Rho et al 1993;Samelin et al 1996;McNamara et al 2005;McNamara et al 2006a), ultrasonic measurement (Rho et al 1993) and nanoindentation (Rho et al 1997;Rho et al 1999;Zysset et al 1999;Hoffler et al 2000;Ferguson et al 2003;Ozcivici et al 2008).…”

Section: Introductionmentioning

confidence: 99%

“…Reported values for the elastic modulus of trabecular and cortical tissue from these studies have conflicted, with values ranging from 0.75GPa to 30GPa (Runkle and Pugh 1975;Townsend et al 1975;Mente and Lewis 1989;Ryan and Williams 1989;Choi et al 1990;Rho et al 1993;Samelin et al 1996;Rho et al 1997;Rho et al 1998;Rho et al 1999;Zysset et al 1999;Hoffler et al 2000;Ferguson et al 2003;McNamara et al 2006a;Ozcivici et al 2008;McNamara 2011). There is much contention regarding whether cortical and trabecular bone are fundamentally the same tissue, and that it is their tissue organisation that distinguishes their mechanical behaviour, or whether the tissue composition and mechanical properties are different between the two bone types.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A three-scale finite element investigation into the effects of tissue mineralisation and lamellar organisation in human cortical and trabecular bone

Vaughan

McCarthy

McNamara

2012

Journal of the Mechanical Behavior of Biomedical Materials

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A three-scale finite element investigation into the effects of tissue mineralisation and lamellar organisation in human cortical and trabecular bone

Vaughan

McCarthy

McNamara

2012

Journal of the Mechanical Behavior of Biomedical Materials

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“…It has also been shown that complex changes in the tissue level mechanical properties and composition occur following oestrogen deficiency in both the tibia and femur in animal models (Brennan et al 2011b;McNamara et al 2006). Specifically, it was seen that mechanical properties of trabecular bone in tibiae of ovariectomized rats are altered over time compared to sham-operated controls (McNamara et al 2006;McNamara and Prendergast 2005).…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of osteocyte stimulation in osteoporosis

Verbruggen

Vaughan

McNamara

2016

Journal of the Mechanical Behavior of Biomedical Materials

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Experimental studies have shown that primary osteoporosis caused by oestrogen-deficiency results in localised alterations in bone tissue properties and mineral composition. Additionally, changes to the lacunar-canalicular architecture surrounding the mechanosensitive osteocyte have been observed in animal models of the disease. Recently, it has also been demonstrated that the mechanical stimulation sensed by osteocytes changes significantly during osteoporosis.Specifically, it was shown osteoporotic bone cells experience higher maximum strains than healthy bone cells after short durations of oestrogen deficiency. However, in long-term oestrogen deficiency there was no significant difference between bone cells in healthy and normal bone. The mechanisms by which these changes arise are unknown. In this study, we test the hypothesis that complex changes in tissue composition and lacunar-canalicular architecture during osteoporosis alter the mechanical stimulation of the osteocyte. The objective of this research is to employ computational methods to investigate the relationship between changes in bone tissue composition and microstructure and the mechanical stimulation of osteocytes during osteoporosis. By simulating physiological loading, it was observed that an initial decrease in tissue stiffness (of 0.425 GPa) and mineral content (of 0.66 wt% Ca) relative to controls could explain the mechanical stimulation observed at the early stages of oestrogen deficiency (5 weeks post-OVX) during in situ bone cell loading in an oestrogendeficient rat model of post-menopausal osteoporosis (Verbruggen et al. 2015). Moreover, it was found that a later increase in stiffness (of 1.175 GPa) and mineral content (of 1.64 wt% Ca) during long-term osteoporosis (34 weeks post-OVX), could explain the mechanical stimuli previously observed at a later time point due to the progression of osteoporosis. Furthermore, changes in canalicular tortuosity arising during osteoporosis were shown to result in increased osteogenic strain stimulation, though to a lesser extent than has been observed experimentally.The findings of this study indicate that changes in the extracellular environment during osteoporosis, arising from altered mineralisation and lacunar-canalicular architecture, lead to altered mechanical stimulation of osteocytes, and provide an enhanced understanding of changes in bone mechanobiology during osteoporosis.

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“…Back scattered electron microscopy (BSEM), Fourier-transformed infrared spectroscopy (FTIP) and energy dispersive X-ray (EDX) spectrometry have all been used to quantify the mineral ultrastructure of bone tissue from both human and rat [9][10][11][12]. These studies demonstrated that the details of bone mineral content and tissue material properties change during osteoporosis [11,13,14] which suggests that tissue mechanical properties are also changed during osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

Cancellous bone lamellae strongly affect microcrack propagation and apparent mechanical properties: Separation of patients with osteoporotic fracture from normal controls using a 2D nonlinear finite element method (biomechanical stereology)

Wang

Zauel

Rao

et al. 2008

Bone

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Biomechanical stereology is proposed as a two-dimensional (2D) finite element (FE) method to estimate the ability of bone tissue to sustain damage and to separate patients with osteoporotic fracture from normal controls. Briefly, 2D nonlinear compact tension FE models were created from quantitative back scattered electron images taken of iliac crest bone specimens collected from the individuals with or without osteoporotic fracture history. The effects of bone mineral microstructure on predicted bone fracture toughness and microcrack propagation were examined. The 2D FE models were used as surrogates for the real bone tissues. The calculated microcrack propagation results and bone mechanical properties were examined as surrogates for measurements from mechanical testing of actual specimens. The results for the 2D FE simulation separated patients with osteoporotic fracture from normal controls even though only the variability in tissue mineral microstructure was used to build the models. The models were deliberately created to ignore all differences in mean mineralization. Hence, the current results support the following hypotheses: (1) that material heterogeneity is important to the separation of patients with osteoporotic fracture from normal controls and; and (2) that 2D nonlinear finite element modeling can produce surrogate mechanical parameters that separate patients with fracture from normal controls.

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Strength of cancellous bone trabecular tissue from normal, ovariectomized and drug-treated rats over the course of ageing

Cited by 75 publications

References 49 publications

A three-scale finite element investigation into the effects of tissue mineralisation and lamellar organisation in human cortical and trabecular bone

A three-scale finite element investigation into the effects of tissue mineralisation and lamellar organisation in human cortical and trabecular bone

Mechanisms of osteocyte stimulation in osteoporosis

Cancellous bone lamellae strongly affect microcrack propagation and apparent mechanical properties: Separation of patients with osteoporotic fracture from normal controls using a 2D nonlinear finite element method (biomechanical stereology)

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