This paper examines the fundamental mechanical properties of masonry elements incorporating fired-clay bricks and hydraulic lime mortars under ambient-dry and wet conditions, corresponding to 48 h submersion in water. In addition to complementary material characterisation assessments, two types of specimens are tested: cylindrical cores in compression, and wall elements in compression. Overall, a detailed account of more than 50 tests is given. Apart from conventional measurements, the use of digital image correlation techniques enables a detailed assessment of the influence of moisture on the constitutive response, confinement effects and mechanical properties of masonry components. The uniaxial compressive strengths of wet brick elements and brick-mortar components, resulting from tests on cylindrical cores with height-to-depth ratios of around two, are shown to be 13-18% lower than those in ambient-dry conditions. The tests also show that enhanced confinement levels in brick units mobilise 67-92% higher strengths than in the corresponding unconfined cylinders. Moreover, experimental observations indicate that the presence of significant confinement reduces the influence of moisture on the mechanical properties as a function of the brick and mortar joint thickness and their relative stiffness. As a result, the failure of wet masonry walls in compression is found to be only marginally lower than those in ambient-dry conditions. Based on the test results, the influence of moisture on the constitutive response and mechanical properties of masonry components is discussed, and considerations for practical application are highlighted.