Strengthening Africa's response to Mpox (monkeypox): insights from historical outbreaks and the present global spread

Olawade, David B.; Wada, Ojima Z.; Fidelis, Sandra Chinaza; Oluwole, Oluwafemi S.; Alisi, Chibuike S.; Orimabuyaku, Nifemi F.; Clement David-Olawade, Aanuoluwapo

doi:10.1016/j.soh.2024.100085

Science in One Health

2024

DOI: 10.1016/j.soh.2024.100085

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Strengthening Africa's response to Mpox (monkeypox): insights from historical outbreaks and the present global spread

David B. Olawade,

Ojima Z. Wada,

Sandra Chinaza Fidelis

et al.

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2024

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Cited by 2 publications

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Sustainable and portable CRISPR-based diagnostics for high-sensitivity Mpox detection

Hirano,

Yoshimi,

Asano

et al. 2024

Preprint

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Mpox has emerged as a critical public health challenge, creating an urgent need for rapid, reliable, and field-deployable diagnostic tools for outbreak settings. Here, we present Kairo-CONAN, a novel CRISPR-Cas3-based point-of-care (POC) diagnostic platform for Mpox, engineered for sustainability and portability. This system leverages a disposable hand warmer (Kairo) as a stable heat source and incorporates freeze-dried reagents for ambient temperature stability, enabling device-free, sensitive detection through lateral flow assay strips. Utilizing CRISPR-Cas3's unique DNA-targeting and cleavage properties, we optimized probe DNA configurations for high specificity and designed clade-specific target crRNAs. Kairo-CONAN demonstrated rapid, high-sensitivity, and specific detection of Mpox virus (MPXV) DNA across multiple clades, including Clade Ia (Congo), Clade Ib (synthetic DNA), and Clade IIb (Tokyo). By addressing logistical and environmental challenges, Kairo-CONAN offers a sustainable, cost-effective, and field-adapted solution for infectious disease diagnostics, aligning with the 100-day mission framework to enhance global outbreak response efforts.

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Sustainable and portable CRISPR-based diagnostics for high-sensitivity Mpox detection

Hirano,

Yoshimi,

Asano

et al. 2024

Preprint

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A cross-sectional study of Mpox Knowledge, Attitudes toward Mpox Vaccination and Mpox Vaccine Hesitancy Among Teachers in Kenya

M.Mutua,

Gicheru,

Mutiso

et al. 2024

Preprint

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Background: Sixteen African countries, including Kenya, reported mpox cases in July and August, prompting the Africa Centers for Disease Control to declare the outbreak a Public Health Emergency of Continental Security on 13th August 2024. The World Health Organization issued an advisory for mpox-related prevention in schools whereby teachers are expected to support mpox-infected students. There is a dearth of information of mpox knowledge and attitudes toward mpox vaccination among teachers in Kenya. Method: An online survey involving 1139 teachers was conducted from 21st August to 3rd October, 2024 to determine the level of mpox knowledge and attitudes toward mpox vaccine and hesitancy factors. Results: The teachers’ mean mpox knowledge score was 8.2 out of 12 whereas the mean mpox attitude score was 3.7 out of 6. At the time of the survey, more than 34 % of the respondents were not aware of mpox cases in the country. The hesitancy rate for vaccination was 49.78 %. More than 62 % of participants cited concerns about vaccine side effects as the main reason for hesitancy. However, participants with certificate and diploma were more likely to accept to be vaccinated against mpox. Only 1.23 % of the participants received mpox information from the Teachers Service Commission. This study identifies gaps in mpox knowledge and attitudes toward mpox vaccination. It suggests that collaboration between the Teachers Service Commission and healthcare providers can ensure effective school community-based prevention strategies by improving mpox knowledge and attitudes toward mpox vaccination among teachers in Kenya.

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Strengthening Africa's response to Mpox (monkeypox): insights from historical outbreaks and the present global spread

Cited by 2 publications

References 94 publications

Sustainable and portable CRISPR-based diagnostics for high-sensitivity Mpox detection

Sustainable and portable CRISPR-based diagnostics for high-sensitivity Mpox detection

A cross-sectional study of Mpox Knowledge, Attitudes toward Mpox Vaccination and Mpox Vaccine Hesitancy Among Teachers in Kenya

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