To introduce the special issue on local food initiatives in the world’s cities, this editorial examines the role of scale and the governance of local food initiatives in cities. The seven papers in this issue focus variously on food system governance at the scales of metropolitan regions, neighborhoods, households, and individual consumers. Although local food initiatives must work to overcome structural challenges operating at global and national scales, as delineated in key literature on food systems, taken together, the seven articles suggest that more sustainable outcomes are possible if local initiatives embrace change across multiple scales.