STrengthening the REporting of Genetic Association Studies (STREGA)—an extension of the STROBE statement

“…Indeed, the concerns expressed by Charney and English echo previously published official guidelines in the genetics community. After noting that "making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics," the baseline recommendation of the relevant report (known as STREGA) is not that CGA studies be discontinued but rather that the quality of the research design and the "transparency of reporting" be enhanced (Little et al 2009). …”

Section: Discussionmentioning

confidence: 99%

Candidate Genes and Voter Turnout: Further Evidence on the Role of 5-HTTLPR

Deppe¹,

Stoltenberg²,

Smith³

et al. 2013

Am Polit Sci Rev

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Recently in this journal, Charney and English (2012) presented an extensive critique of candidate gene association studies using the widely noted Fowler and Dawes (2008) article on the relationship between self-reported voter turnout and both 5-HTT (serotonin transporter) and MAOA (monoamine oxidase A) as the driving example of their evaluation. Reanalysis of the Fowler and Dawes data by Charney and English, based on four critiques of candidate gene studies, led to the conclusion that neither polymorphism is related to variations in turnout. We add to this empirical debate by conducting an independent test using an original dataset containing 5-HTT data and two separate participation variables: self-reported participation and actual voting records. Our results confirm the original conclusions by Fowler and Dawes on 5-HTT, but also support several of the critiques suggested by Charney and English. We conclude by offering suggestions for the way candidate gene association studies should be interpreted by the discipline and processed by journal editors.

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“…Randomized controlled trials CONSORT extension to cluster randomized trials 12 Cluster randomized trials CONSORT extension to noninferiority/equivalence trials 13 Noninferiority/equivalence trials CONSORT for TCM 14 Trials of traditional Chinese medicine CONSORT extension to nonpharmacological treatment 15 Trials of nonpharmacological treatment STROBE 16 Observational studies STROBE-ME 17 Molecular epidemiology studies STREGA 18 Genetic association studies RECORD 19 Observational studies conducted using routinely collected health data REMARK 20 Tumor marker prognostic studies and information presented in an obscure or less than optimum format. 10 A large systematic review that was updated in 2012 assessed the effect of journal endorsement of the CONSORT checklist.…”

Section: Consort 11mentioning

confidence: 99%

Better reporting quality for improved pediatric investigation: Application of health research reporting guidelines

Peng

Nie

2017

Pediatric Investigation

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Clinical research on the accuracy of diagnostic tests, the power of prognostic markers, and the efficacy and safety of interventions are the cornerstone of evidence-based health care. 1 Transparency and sufficient reporting are important for conveying research findings to the public, practitioners, and students in medicine because insufficient reporting of results would hinder assessment for a study's strengths and weaknesses and thus hamper integration of evidence, even from well-conducted research. 2 However, the reporting quality of articles in most healthcare journals remains inadequate. [3][4][5][6] Many publications lack clarity, transparency, and completeness on how the authors actually carry out their research. Therefore, the validity of research cannot be accurately evaluated. An example of such situation is that determining whether randomization is sufficient is difficult if authors do not report important information (eg, generation of random sequences and the method of random concealment in therapeutic assessment studies). 7 Reviewers and readers will not make an information-based assessment on research quality and the risk of bias if the reporting quality is insufficient as well as reviewers and readers could not get linkage to a research protocol. was found in the research in a clear and transparent manner. In particular, these guidelines can emphasize the issues that might introduce bias to the research. Work groups that developed types of reporting guidelines have declared that reporting guidelines are recommended for researchers, but not to be demanded. However, researchers can improve the research design by referring to the checklists of a reporting guideline. Moreover, we must be aware that reporting guidelines do not recommend how specific studies should be designed, ----------------------------------------------------------------------------------------------------------------------------------------------------------------------This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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STrengthening the REporting of Genetic Association Studies (STREGA)—an extension of the STROBE statement

Cited by 290 publications

References 144 publications

Functional variant ANXA11 R230C: true marker of protection and candidate disease modifier in sarcoidosis

Functional variant ANXA11 R230C: true marker of protection and candidate disease modifier in sarcoidosis

Candidate Genes and Voter Turnout: Further Evidence on the Role of 5-HTTLPR

Better reporting quality for improved pediatric investigation: Application of health research reporting guidelines

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