2021
DOI: 10.1001/jama.2021.18236
|View full text |Cite
|
Sign up to set email alerts
|

Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization

Abstract: IMPORTANCE Mendelian randomization (MR) studies use genetic variation associated with modifiable exposures to assess their possible causal relationship with outcomes and aim to reduce potential bias from confounding and reverse causation. OBJECTIVE To develop the STROBE-MR Statement as a stand-alone extension to the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) guideline for the reporting of MR studies. DESIGN, SETTING, AND PARTICIPANTS The development of the STROBE-MR Statement… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

8
779
0
1

Year Published

2021
2021
2024
2024

Publication Types

Select...
6

Relationship

1
5

Authors

Journals

citations
Cited by 1,814 publications
(986 citation statements)
references
References 31 publications
8
779
0
1
Order By: Relevance
“…30 We revised the checklist in the light of the comments received and produced an article presenting the STROBE-MR statement. 27 The STROBE-MR reporting guidelines are meant to apply to studies that use properties of germline genetic variants to strengthen causal inference regarding possible effects of potentially modifiable exposures on outcomes. The two principal types of MR studies are Box 1: Scope of mendelian randomisation (MR) and the STROBE-MR checklist While MR generally uses genetic variation as the instrumental variable, MR is not limited to such studies.…”
Section: Development Scope and Intended Use Of Strobe-mrmentioning
confidence: 99%
See 4 more Smart Citations
“…30 We revised the checklist in the light of the comments received and produced an article presenting the STROBE-MR statement. 27 The STROBE-MR reporting guidelines are meant to apply to studies that use properties of germline genetic variants to strengthen causal inference regarding possible effects of potentially modifiable exposures on outcomes. The two principal types of MR studies are Box 1: Scope of mendelian randomisation (MR) and the STROBE-MR checklist While MR generally uses genetic variation as the instrumental variable, MR is not limited to such studies.…”
Section: Development Scope and Intended Use Of Strobe-mrmentioning
confidence: 99%
“…Some STROBE items are either too general or do not apply to MR studies, while other items relevant to MR studies are missing. To improve reporting MR studies, we developed a separate checklist of items motivated by the STROBE guidelines but explicitly focused on the MR study design, resulting in the STROBE-MR statement (strengthening the reporting of observational studies in epidemiology using mendelian randomisation 27 ; table 3 ). Similar to the STROBE checklist, the STROBE-MR items relate to the title, abstract, introduction, methods, results, and discussion sections of articles.…”
Section: Strengthening the Reporting Of Mr Studiesmentioning
confidence: 99%
See 3 more Smart Citations