“…Furthermore, RNase 2, 3, 5, and 7 participate in regulating allergies or immune diseases of the skin, the respiratory system, and the gut ( Lu et al., 2018 ). In tumors, RNase 5 has been shown to promote tumor growth and metastasis ( Sheng and Xu, 2016 ); however, RNase 1 is considered as candidate therapy for tumors ( Castro et al., 2021 ). In neurological disorders, RNase 2 and 3 are considered risk factors because of their potential neurotoxicity ( Singh and Batra, 2011 ), whereas RNase 4 and 5 are found as neuroprotective factors ( Li et al., 2013 ; Sebastià et al., 2009 ).…”