Strepsils® Tablets Reduce Sore Throat and Hoarseness After Tracheal Intubation

Ebneshahidi, Amin; Mohseni, Masood

doi:10.1213/ane.0b013e3181d00c60

Cited by 48 publications

(30 citation statements)

References 12 publications

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“…Although it seems to be a trivial adverse effect, especially with the addition of hoarseness and dysphagia, it may negatively affect patient comfort and lead to postoperative morbidity (7). Even though POST frequently occurs after endotracheal intubation, some patients may also suffer from sore throat after laryngeal mask airway (LMA) insertion (1).…”

mentioning

confidence: 99%

The Effect of Flurbiprofen on Postoperative Sore Throat and Hoarseness After LMA-ProSeal Insertion: A Randomised, Clinical Trial

Uztüre¹,

Menda²,

Bilgen³

et al. 2014

Turk J Anesth Reanim

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Objective: We hypothesized that flurbiprofen lozenges reduce the ProSeal laryngeal mask airway (LMA) related symptoms of Post Operative Sore Throat (POST), hoarseness and dysphagia compared to placebo lozenges.Methods: Eighty American Society of Anesthesiologists (ASA) I-II patients undergoing general anaesthesia with LMA were included in this prospective, randomized, placebo-controlled clinical and single centre (university hospital) study. Group F received an 8.75 mg flurbiprofen lozenge (Strefen ® ) and Group P received a placebo lozenge 45 minutes before the induction of anaesthesia. Postoperative sore throat, hoarseness and dysphagia were evaluated 30 minutes after removal of the LMA in the recovery room and then at 4, 12 and 24 h after surgery using a 4-point scale. Data were analysed using Student's t test, and Fisher's exact and Mann-Whitney U tests. A p value of <0.05 was considered statistically significant.Results: The 8.75 mg flurbiprofen lozenges reduced the severity of early (30 mins) POST and dysphagia. The severity of dysphagia at 4 h and hoarseness at 12 h were also significantly reduced in Group F. There were no significant differences betweeen the groups regarding incidence of sore throat, dysphagia and hoarseness throughout the study period.

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mentioning

confidence: 99%

The Effect of Flurbiprofen on Postoperative Sore Throat and Hoarseness After LMA-ProSeal Insertion: A Randomised, Clinical Trial

Uztüre¹,

Menda²,

Bilgen³

et al. 2014

Turk J Anesth Reanim

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“…[6][7][8][9][10] Different methods have been proposed to decrease the adverse effects associated with mucosal irritation caused by the endotracheal tube (ETT), including the administration of opioids, extubation under deep anesthesia, use of fluticasone, and injection of intravenous lidocaine. 4,[10][11][12][13][14][15] Although intravenous anesthetics have been shown to be effective in reducing the incidence of cough at emergence, time can be delayed until the patient can respond to simple orders. 16 Thus, topical local anesthetics represent an attractive alternative to suppress cough while maintaining rapid awakening.…”

mentioning

confidence: 99%

The effects of lidocaine spray and intracuff alkalinized lidocaine on the occurrence of cough at extubation: a double-blind randomized controlled trial

D’Aragon

Beaudet

Gagnon

et al. 2013

Can J Anesth/J Can Anesth

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Purpose Our study aimed to evaluate the effects of lidocaine sprayed onto the larynx and/or injected into the tracheal tube cuff to decrease the incidence of cough at extubation and postoperative sore throat. Methods One hundred twenty women scheduled for gynecological surgery \ 120 min in duration were enrolled in this randomized double-blind prospective study. Prior to tracheal intubation, 4% lidocaine or 0.9% saline was sprayed onto the patients' supra-and subglottic areas.After tracheal intubation, the tracheal tube cuff was filled with either an alkalinized 2% lidocaine solution or 0.9% saline. This resulted in four groups: spray-cuff, spray-saline, saline-cuff, and saline-saline. A logistic regression comprising the two factors was used for analysis. The primary outcome was the incidence of cough at extubation. The secondary outcome was the incidence and severity of sore throat reported by patients at 15 min, 60 min, and 24 hr after tracheal extubation. Results Cough occurred in 42%, 24%, 63%, and 69% of patients in the spray-cuff, spray-saline, saline-cuff, and saline-saline groups, respectively. The use of lidocaine spray decreased the incidence of cough at extubation (odds ratio = 0.256; 95% confidence interval 0.118 to 0.554; P \ 0.001); however, the use of intracuff alkalinized lidocaine had no impact on the occurrence of cough (P = 0.471). Severity of sore throat was clinically low (visual analog scale [VAS] B 3) in all groups. No significant difference was observed in hoarseness, dysphagia, nausea, or vomiting. Conclusion Sprayed lidocaine decreases the incidence of cough at tracheal extubation in surgeries of less than two hours. The use of alkalinized lidocaine into high-volume/ low-pressure endotracheal cuffs had no impact on decreasing the incidence of cough or pain.

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“…3 Tindakan farmakologi untuk mencegah nyeri tenggorok yang dapat dilakukan adalah dengan cara memberikan inhalasi flutikason, steroid topikal, kumur-kumur dengan azulen sulfonat, non steroidal antiinflammatory drugs (NSAID), benzidamin hidroklorid, antagonis reseptor N-methyl D-aspartate (NMDA) yaitu ketamin, deksametason intravena, permen strepsils ® . [8][9][10][11][12][13] Dari penelitian sebelumnya yang membandingkan gel betametason dengan gel air diketahui kejadian nyeri tenggorok serta suara serak menurun pada 1 jam dan 24 jam pertama. 14 Benzidamin HCl merupakan suatu NSAID, namun secara farmakologis mempunyai efek yang sangat berbeda dengan golongan NSAID pada umumnya, yaitu mempunyai sedikit atau juga bahkan sama sekali tidak memiliki efek terhadap sintesis prostanoid.…”

Section: Pendahuluanunclassified

Perbandingan Penggunaan Topikal Spray Benzidamin HCl 0,15% dan Gel Lidokain 2% pada Pipa Endotrakeal terhadap Kejadian Nyeri Tenggorok Pascaintubasi Endotrakeal

Muhammad¹,

Fuadi²,

Nawawi³

2015

jap

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Strepsils® Tablets Reduce Sore Throat and Hoarseness After Tracheal Intubation

Abstract: Perioperative use of Strepsils tablets reduces postoperative sore throat and hoarseness of voice.

Cited by 48 publications

References 12 publications

The Effect of Flurbiprofen on Postoperative Sore Throat and Hoarseness After LMA-ProSeal Insertion: A Randomised, Clinical Trial

The Effect of Flurbiprofen on Postoperative Sore Throat and Hoarseness After LMA-ProSeal Insertion: A Randomised, Clinical Trial

The effects of lidocaine spray and intracuff alkalinized lidocaine on the occurrence of cough at extubation: a double-blind randomized controlled trial

Perbandingan Penggunaan Topikal Spray Benzidamin HCl 0,15% dan Gel Lidokain 2% pada Pipa Endotrakeal terhadap Kejadian Nyeri Tenggorok Pascaintubasi Endotrakeal

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