Streptocerciasis: Degeneration of Adult Dipetalonema Streptocerca in Man Following Diethylcarbamazine Therapy *

Wm, Meyers; Moris, R; Rc, Neafie; Dh, Connor; Bourland, J. Daniel

doi:10.4269/ajtmh.1978.27.1137

Cited by 12 publications

(5 citation statements)

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“…Adverse side-effects after ivermectin treatment of streptocerciasis were similar to those observed in onchocerciasis (WHO 1995), most commonly pruritus and papular dermatitis, as seen in streptocerciasis after DEC treatment by Duke (1957) and Meyers et al (1972;1978). The absence of complaints for severe systemic reactions may have been due to the low mf densities of the examined persons.…”

Section: Figuresupporting

confidence: 53%

“…Frequently found co-infections with Onchocerca volvulus (Sasa 1976; own unpublished data from Ghana, Togo and Gabon) further impede the evaluation of drug effects on M. streptocerca. Wanson and co-workers (1950) reported a microfilaricidal treatment of 42 patients with M. streptocerca infection with diethylcarbamazine (DEC); their findings were confirmed by Duke (1957) and Meyers et al (1972;1978). Meyers et al (1978) also reported efficacy of DEC against adult filaria.…”

Section: Introductionsupporting

confidence: 57%

“…Wanson and co-workers (1950) reported a microfilaricidal treatment of 42 patients with M. streptocerca infection with diethylcarbamazine (DEC); their findings were confirmed by Duke (1957) and Meyers et al (1972;1978). Meyers et al (1978) also reported efficacy of DEC against adult filaria. However, due to frequent co-infections with O. volvulus, the value of DEC for the treatment of streptocerciasis is limited.…”

Section: Introductionsupporting

confidence: 57%

“…Whereas earlier authors did not observe skin disease on M. streptocerca microfilaria (mf) carriers (Wanson et al 1950;Sasa 1976), papular dermatitis was later reported (Duke 1957;Meyers et al 1978). Usually, skin disease in streptocerciasis is described as mild and considered to have little medical significance, so only a few reports on its chemotherapy exist.…”

Section: Introductionmentioning

confidence: 93%

“…A few developed larger papules after ivermectin treatment ( Figure 4D), which corresponded to the description of Meyers and co-workers (1978) for papules after DEC treatment. Meyers et al (1978) detected adult female worms in the larger papules.…”

Section: Side-effectsmentioning

confidence: 99%

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Treatment of human Mansonella streptocerca infection with ivermectin

Fischer

Bamuhiiga

Büttner

1997

Tropical Med Int Health

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SummaryWe studied the short-term effects of a single dose of 150 g/kg body weight ivermectin on Mansonella streptocerca in an area endemic for streptocerciasis, but not for onchocerciasis, in western Uganda. Six and 12 days after treatment no microfilariae (mf) were found in the skin of 53 out of 96 mf carriers living in 3 villages, and the geometric means of the mf densities of remaining mf carriers were only 33-40% of pretreatment levels. This reduction of mf density was highly significant (P<0.0001). Immunohistological examination of skin biopsies showed degenerated and disintegrating mf surrounded by activated eosinophils (positive for activated cationic protein), macrophages, and neutrophils (positive for myeloperoxidase and defensin) on day 6 after treatment. Remarkable was the invasion of young, L1 protein-positive macrophages and the release of neutrophil defensin as signs of acute inflammation. We conclude that ivermectin has a strong microfilaricidal activity against M. streptocerca. Common adverse effects were increased pruritus and acute papular dermatitis in 45% of 86 mf carriers on day 6 after treatment. No serious adverse side-effects were noticed in about 700 treated persons.

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Section: Figuresupporting

confidence: 53%