Streptococcal Rheumatic Carditis.

Unny, S K; Middlebrooks, B. L.

doi:10.1097/00006454-198307000-00034

Cited by 8 publications

(9 citation statements)

References 70 publications

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“…In the present study most patients with RF/RHD (55.3%) had antibodies to more than one OF type. Reviewing outbreaks of RF, St~llerman'~ found that a limited number of serotypes were involved (M-types 5,18, 19,24) and that none of these produced OF. However, M-420 and M-1 1 14* 21 OF-positive serotypes have been reported to be associated with RF.…”

Section: Discussionmentioning

confidence: 99%

Antibodies to streptococcal opacity factor in a selected Indian population

Prakash

Dutta²

1991

Journal of Medical Microbiology

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Summary. Antibody to at least one type of streptococcal opacity factor (OF) was present in 39.0% of 235 selected subjects and, in 4743% of these, to more than one type. Only 21.6% of children less than 4 years old had antibody to OF; these were to one type in 62.5% or to more than one in 37.5%. In the study group as a whole, the commonest antibodies were those to OF from M-serotype 25 followed, in descending order, by serotypes 4,22,2,9,48,49,28,61 and 75. Patients with rheumatic fever or rheumatic heart disease most often had antibodies to OF from M-types 25, 22, 4 and 9, whereas in patients with acute glomerulonephritis, antibodies to OF from M-types 48,49 and 61 were commonest. The limitations of the OFinhibition test as an epidemiological marker for prevalent M-types of group A streptococci are discussed.

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Section: Discussionmentioning

confidence: 99%

Antibodies to streptococcal opacity factor in a selected Indian population

Prakash

Dutta²

1991

Journal of Medical Microbiology

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“…Therefore, most animal models which have been reported have relied on immunization of rabbits, mice, rats, and monkeys (114,115,166,191,192,(473)(474)(475)(476)548). A review by Unny and Middlebrook on rheumatic carditis described many early studies of rheumatic fever in animals, noting the streptococcal antigen used, the type of immunization, and the ani- mal tested (525). Most of the preparations used in the animal studies were whole streptococci or crude streptococcal preparations.…”

Section: Autoimmunity and Molecular Mimicry In Rheumatic Fevermentioning

confidence: 99%

Pathogenesis of Group A Streptococcal Infections

Cunningham

2000

Clinical Microbiology Reviews

1,607

1,337

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“…Carditis is the most serious manifestation of ARF, causing both morbidity and mortality, and is the leading cause of acquired childhood heart disease worldwide [4-11]. Patients with rheumatic heart disease (RHD) develop valvulitis characterized by mitral stenosis and aortic regurgitation [12, 13]. …”

Section: Introductionmentioning

confidence: 99%

Identification of Streptococcal M-Protein Cardiopathogenic Epitopes in Experimental Autoimmune Valvulitis

Kirvan

Galvin

Hilt

et al. 2013

J. of Cardiovasc. Trans. Res.

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The M protein of rheumatogenic group A streptococci induces carditis and valvulitis in Lewis rats and may play a role in pathogenesis of rheumatic heart disease. To identify epitopes of M5 protein that produce valvulitis, synthetic peptides spanning A, B, and C repeat regions contained within the extracellular domain of the streptococcal M5 protein were investigated. A repeat region peptides NT4, NT5/6, and NT7 induced valvulitis similar to the intact pepsin fragment of M5 protein. T cell lines from rats with valvulitis recognized M5 peptides NT5/6 and NT6. Passive transfer of an NT5/6-specific T cell line into naïve rats produced valvulitis characterized by infiltration of CD4+ cells and upregulation of VCAM-1, while an NT6-specific T cell line did not target the valve. Our new data suggests that M protein-specific T cells may be important mediators of valvulitis in the Lewis rat model of rheumatic carditis.

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Streptococcal Rheumatic Carditis.

Cited by 8 publications

References 70 publications

Antibodies to streptococcal opacity factor in a selected Indian population

Antibodies to streptococcal opacity factor in a selected Indian population

Pathogenesis of Group A Streptococcal Infections

Identification of Streptococcal M-Protein Cardiopathogenic Epitopes in Experimental Autoimmune Valvulitis

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