Streptococcus agalactiae strains isolated from cancer patients in Rio de Janeiro, Brazil

Sanches, Glenda F.; Lannes-Costa, Pamella Silva; Cristoforêto, Melissa Coimbra; Doran, Kelly S.; Guaraldi, Ana Luíza de Mattos; Nagao, Prescilla Emy

doi:10.1007/s42770-020-00419-6

Cited by 5 publications

(2 citation statements)

References 43 publications

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“…An Australian study found 32% co-resistance of clindamycin and erythromycin in 100 S. agalactiae strains (Jones et al, 2022). In Iran, the multiple-resistance rate of S. agalactiae was approximately 22% (Motallebirad et al, 2021), while in Brazil, one S. agalactiae strain exhibited a multidrug resistance pattern (de Figueiredo et al, 2021a). These studies, including our study, suggest the worsening of clindamycin resistance in S. agalactiae globally.…”

Section: Discussionsupporting

confidence: 57%

Molecular characteristics and antibiotic resistance mechanisms of clindamycin-resistant Streptococcus agalactiae isolates in China

Liu

Jiang

et al. 2023

Front. Microbiol.

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Streptococcus agalactiae (Group B Streptococcus, GBS) is a major cause of neonatal infections with high morbidity and mortality, and clindamycin is the main antibiotic used to treat GBS infections in patients allergic to penicillin. We aimed to analyse the antibiotic sensitivity, sequence types, serotypes, virulence factors, and antibiotic resistance mechanisms of clinically isolated clindamycin-resistant S. agalactiae and provide basic data for the treatment, prevention, and control of clinical infection of S. agalactiae. A total of 110 strains of clindamycin-resistant S. agalactiae were collected from two tertiary hospitals in Hebei, China. We performed antibiotic sensitivity tests for 11 antibiotics on these strains and whole-genome sequencing analysis. All the strains were susceptible to penicillin, ampicillin, linezolid, vancomycin, tigecycline, and quinupristin–dalfopristin. Resistance to erythromycin, levofloxacin, tetracycline, and chloramphenicol were also observed. Genome sequence analysis revealed that all strains belonged to 12 sequence types (STs) related to six cloning complexes (CCs), namely CC10, CC19, CC23, CC651, CC1, and CC17. Five serotypes were identified, including IA, IB, II, III, and V. The most prominent resistance genes were mreA (100%) and ermB (81.8%). Furthermore, cfb, cylE, pavA and the gene cluster related to the pili were 100% present in all strains, followed by lmb (95.5%) and srr1 (67.2%). This study found that clindamycin-resistant S. agalactiae showed polymorphisms in molecular types and serotypes. Furthermore, multiple virulence factor genes have been identified in their genomes.

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Section: Discussionsupporting

confidence: 57%

Molecular characteristics and antibiotic resistance mechanisms of clindamycin-resistant Streptococcus agalactiae isolates in China

Liu

Jiang

et al. 2023

Front. Microbiol.

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“…Streptococcus agalactiae , commonly known as Lancefield Group B Streptococcus (GBS), is a typically harmless bacterium present in the genital tract of healthy women, as well as in the gastrointestinal and urinary tracts of healthy adults [ 1 ]. Although GBS infections are more frequently encountered in newborns and can manifest severely, causing conditions like bacteremia and meningitis [ 2 ], instances of this opportunistic pathogen causing bacteremia in elderly individuals or adults with compromised immune systems, such as those with diabetes or cancer, have been documented [ 2 , 3 ]. Nevertheless, its association with infectious pleurisy or septic arthritis is rare [ 4 , 5 ], with no reported cases of both conditions being attributed to GBS simultaneously.…”

Section: Introductionmentioning

confidence: 99%

A Case of Dual Septic Foci in Both the Joint and Pleural Cavity Caused by Streptococcus agalactiae

Saley Younoussa,

Benaissa,

Ben Lahlou

et al. 2024

Cureus

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Group B Streptococcus (GBS or Streptococcus agalactiae ) is a common component of the human flora. However, infections in adults are infrequent, and occurrences of infectious pleurisy or septic arthritis are exceedingly uncommon. To our knowledge, the concurrent manifestation of both conditions has not been previously documented. We present the case of a 61-year-old man who exhibited an unusual association of infectious pleurisy and septic arthritis in the knee, both attributed to GBS. The patient was admitted to the hospital due to thoracic pain and discomfort in the left knee. Clinical examination revealed a pleural effusion in the left lung and arthritis in the left knee. Synovial and pleural fluid samples were sent to the bacteriology laboratory for cytobacteriological examination, confirming the presence of GBS in both fluids. The patient is diabetic and has a history of undergoing total cystoprostatectomy for a urothelial tumor, with the placement of a mono J catheter. The prevailing hypothesis suggests that the colonization of the mono J catheter, followed by hematogenous dissemination, is the probable source of the infection. This unusual clinical case underscores GBS's ability to induce severe invasive infections in adults, particularly in those with underlying medical conditions.

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Molecular characterization, antimicrobial resistance and invasion of epithelial cells by Streptococcus agalactiae strains isolated from colonized pregnant women and newborns in Rio de Janeiro, Brazil

Pimentel,

Lannes-Costa,

Viana

et al. 2024

Journal of Applied Microbiology

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Aims To evaluate the prevalence, molecular characteristics, antimicrobial susceptibility and epithelial invasion of S. agalactiae strains isolated from pregnant women and newborns in Rio de Janeiro, Brazil. Methods and results A total of 67 S. agalactiae isolates, 48 isolates from pregnant women and 19 from neonates, were analyzed. Capsular type Ia and V were predominant (35.8%/each). The MLST analysis revealed the presence of 19 STs grouped into 6 clonal complexes with prevalence of CC17/40.3% and CC23/34.3%. The lmb and iag virulence genes were found in 100% of isolates. Four S. agalactiae strains, belonging to CC17/ST1249 and CC23/ST23, were able to adhere to A549 respiratory epithelial cells. Antimicrobial resistance was verified mainly to tetracycline (85%), erythromycin (70.8%), and clindamycin (58.3%). Four S. agalactiae isolates were multidrug resistant. The resistance genes tested were found in 92.5% of isolates for tetM, 58.2% for ermB, 28.4% for mefAE, and 10.4% for tetO. Conclusion The study showed a high prevalence of virulence and antimicrobial genes in S. agalactiae strains isolated from pregnant women and newborns, supporting the idea that continued surveillance is necessary to identify risk factors and perform long-term follow-up in pregnant women and neonates in Rio de Janeiro.

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Streptococcus agalactiae strains isolated from cancer patients in Rio de Janeiro, Brazil

Cited by 5 publications

References 43 publications

Molecular characteristics and antibiotic resistance mechanisms of clindamycin-resistant Streptococcus agalactiae isolates in China

Molecular characteristics and antibiotic resistance mechanisms of clindamycin-resistant Streptococcus agalactiae isolates in China

A Case of Dual Septic Foci in Both the Joint and Pleural Cavity Caused by Streptococcus agalactiae

Molecular characterization, antimicrobial resistance and invasion of epithelial cells by Streptococcus agalactiae strains isolated from colonized pregnant women and newborns in Rio de Janeiro, Brazil

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