Streptococcus equi subsp. zooepidemicus meningitis in Peru

Mori, Nicanor; Guevara, Jose M.; Tilley, Drake H.; Briceno, Jesus A.; Zunt, Joseph R.; Montano, Silvia M.

doi:10.1099/jmm.0.050245-0

Cited by 17 publications

(12 citation statements)

References 8 publications

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“…However, human SEZ infections have been reported globally and are often linked to consumption of unpasteurized milk or contact with infected animals. Meningitis is the most common clinical manifestation of human infection with SEZ and can be fatal [3, 4].…”

Section: Introductionmentioning

confidence: 99%

A streptococcal Fic domain-containing protein disrupts blood-brain barrier integrity by activating moesin in endothelial cells

Peng

et al. 2019

PLoS Pathog

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Streptococcus equi subsp. zooepidemicus (SEZ) is a zoonotic pathogen capable of causing meningitis in humans. The mechanisms that enable pathogens to traverse the blood-brain barrier (BBB) are incompletely understood. Here, we investigated the role of a newly identified Fic domain-containing protein, BifA, in SEZ virulence. BifA was required for SEZ to cross the BBB and to cause meningitis in mice. BifA also enhanced SEZ translocation across human Brain Microvascular Endothelial Cell (hBMEC) monolayers. Purified BifA or its Fic domain-containing C-terminus alone were able to enter into hBMECs, leading to disruption of monolayer barrier integrity. A SILAC-based proteomic screen revealed that BifA binds moesin. BifA’s Fic domain was required for its binding to this regulator of host cell cytoskeletal processes. BifA treatment of hBMECs led to moesin phosphorylation and downstream RhoA activation. Inhibition of moesin activation or moesin depletion in hBMEC monolayers abrogated BifA-mediated increases in barrier permeability and SEZ’s capacity to translocate across monolayers. Thus, BifA activation of moesin appears to constitute a key mechanism by which SEZ disrupts endothelial monolayer integrity to penetrate the BBB.

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Section: Introductionmentioning

confidence: 99%

A streptococcal Fic domain-containing protein disrupts blood-brain barrier integrity by activating moesin in endothelial cells

Peng

et al. 2019

PLoS Pathog

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“…GCS is a rare cause of bacteremia, mostly associated with zoonological infections 1–8. It can cause a mucopurulent pulmonary disease in horses and mastitis in cattle 2,3.…”

Section: Discussionmentioning

confidence: 99%

Streptococcus group C meningitis with cavernous sinus thrombosis

Clarke¹,

Enuh²,

Saverimuttu³

et al. 2013

IDR

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Group C Streptococcus (GCS) is a rare cause of bacteremia in humans. It is mostly associated with zoonological infections. Although GCS can be part of the normal oral, skin, and genitourinary fora, an infection with this pathogen can be highly virulent, causing rapid, disseminating disease. With a mortality of about 25%, the poor prognosis is linked to the severity of illness and the high level of virulence of the organism. Only a few cases of GCS meningitis have been reported. We present the first case of GCS meningitis with cavernous sinus thrombosis.

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“…The small number of cases identified reflects the low 49 chance of developing S. equi meningitis after horse contact. Unpasteurized dairy products may harbour several 50 pathogens, such as Listeria monocytogenes and Campylobacter jejuni, and consumption is therefore discouraged 51 by the Centers for Disease Control and Prevention [3]. An immunocompromised state was present only in 20% of 52 the patients with S. equi meningitis, compared to 67% of the patients with L. monocytogenes meningitis being of S. equi meningitis were caused by subspecies zooepidemicus, and only two cases were caused by 56 subspecies equi.…”

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confidence: 94%