Streptococcus Milleri-Sepsis With Lung and Brain Abscesses

Velghe, Anja; Noortgate, Nele Van Den; Janssens, Ward; Smeets, Peter; Vogelaers, Dirk

doi:10.1179/acb.2004.054

Cited by 5 publications

(6 citation statements)

References 13 publications

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“…Clinically, the SMG are distinguished by their predilection for severe purulent infections (characterized by the accumulation of pus) (21)(22)(23). They are the etiologic agent in a number of lifethreatening infections, including abscesses of the brain, liver, lung, and empyema (accumulation of pus in the pleural space) (23)(24)(25)(26)(27)(28)(29)(30)(31)(32). SMG infections are thought to result from dissemination from local sites where the SMG are communal members of the microbiota (22,(33)(34)(35).…”

mentioning

confidence: 99%

A polymicrobial perspective of pulmonary infections exposes an enigmatic pathogen in cystic fibrosis patients

Sibley

Parkins²,

Rabin

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

301

310

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Lung disease is the leading cause of morbidity and mortality in cystic fibrosis (CF) patients. A modest number of bacterial pathogens have been correlated with pulmonary function decline; however, microbiological and molecular evidence suggests that CF airway infection is polymicrobial. To obtain a more complete assessment of the microbial community composition and dynamics, we undertook a longitudinal study by using culture-independent and microbiological approaches.In the process, we demonstrated that within complex and dynamic communities, the Streptococcus milleri group (SMG) can establish chronic pulmonary infections and at the onset of 39% of acute pulmonary exacerbations, SMG is the numerically dominant pathogen. We report the comprehensive polymicrobial community dynamics of a CF lung infection in a clinically relevant context. If a given organism, such as Pseudomonas aeruginosa, becomes resistant to antibiotic therapy, an alternative treatment avenue may mediate the desired clinical response by effectively managing the composition of the microbial community.

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mentioning

confidence: 99%

A polymicrobial perspective of pulmonary infections exposes an enigmatic pathogen in cystic fibrosis patients

Sibley

Parkins²,

Rabin

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

301

310

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“…First mechanism is by the spread from a cranial site of infection such as mastoiditis, odontogenic infection, or sinusitis [2,7]. Second mechanism is through hematogenous spread from the respiratory or gastrointestinal tracts [7,8]. In our case, we believe that our patient developed the empyema secondary to his periodontal disease.…”

Section: Discussionmentioning

confidence: 83%

Streptococcus Constellatus Empyema Presenting With Undulant Fever Pattern- A Case Report and Literature Review

George¹,

Tanveer²,

Michael³

2021

Int J Respir Pulm Med

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“…Etken beyin ve karaciğer apselerinden izole edilebilir, ürogenital, plöropulmoner ve gastrointestinal tutulum yapabilir. 2,3 S. anginosus; nadir bir spondilodiskit etkenidir. [5][6][7][8] Piyojenik spondilodiskitler sıklıkla enfekte odaktan hematojen yayılım sonucunda gelişir.…”

Section: Discussionunclassified

“…2 Literatürde, S. anginosus'a bağlı santral sinir sistemi, akciğer, karaciğer, dalakta tek veya multipl apse formasyonu ile karakterize dissemine piyojenik enfeksiyonlar bildirilmiştir. [1][2][3][4] Velghe ve ark., altta yatan solunum yolu enfeksiyonu ve endoftalmiti olan 69 yaşında bir erkek hastada, S. anginosus'a bağlı beyinde tek, akciğerde multipl apse ve sepsis bildirmişlerdir. 3 Hastanın 9 hafta penisilin G ve klindamisin tedavisi ile iyileştiği rapor edilmiştir.…”

Section: Discussionunclassified

“…1 Beyin, karaciğer veya dalak apseleri, karın içi veya yumuşak doku apseleri ve plevral ampiyem gibi süpüratif enfeksiyonlardan sorumlu, nadir görülen bir fırsatçı patojendir. [1][2][3][4][5] S. anginosus'a bağlı spondilodiskit nadiren bildirilmektedir. [5][6][7][8] Bu çalışmada, diş tedavisi sonrasında S. anginosus'a bağlı spondilodiskit gelişen bir olgu sunularak literatür gözden geçirildi.…”

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