Streptococcus pneumoniae-associated Hemolytic Uremic Syndrome

Angurana, Suresh Kumar; Mehta, Ankit; Agrawal, Triptee; Nallasamy, Karthi; Jayashree, Muralidharan

doi:10.1007/s12098-018-2620-5

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…Eculizumab therapy did not seem to worsen S. pneumoniae –induced lung pathology in our patient. The duration of mechanical ventilation and trends of inflammatory markers were similar to other Sp‐HUS patients and S. pneumoniae –associated necrotizing pneumonia reported in the literature 2,13,14 . When possible, eculizumab infusions should be avoided during active infections 15 .…”

Section: Figuresupporting

confidence: 78%

“…The duration of mechanical ventilation and trends of inflammatory markers were similar to other Sp-HUS patients and S. pneumoniae-associated necrotizing pneumonia reported in the literature. 2,13,14 When possible, eculizumab infusions should be avoided during active infections. 15 However, despite the missing bactericidal effect with eculizumab, invasive infections with capsulated organisms such as S. pneumonia or Haemophilus influenza type B are rare as they are prevented mostly by opsonization.…”

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confidence: 99%

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Early initiation of eculizumab therapy for Streptococcus pneumoniae–associated hemolytic uremic syndrome

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Baloğlu

et al. 2020

Pediatric Blood & Cancer

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confidence: 78%

mentioning

confidence: 99%

Early initiation of eculizumab therapy for Streptococcus pneumoniae–associated hemolytic uremic syndrome

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Matar

Baloğlu

et al. 2020

Pediatric Blood & Cancer

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Typical and Atypical Hemolytic Uremic Syndrome in the Critically Ill

Manrique‐Caballero

Peerapornratana

Formeck

et al. 2020

Critical Care Clinics

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Influenza-associated hemolytic uremic syndrome: The pathogenic role of the virus

Silecchia

D’Onofrio

Valerio

et al. 2021

CNCS

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A 3-year-old girl came to our attention for fever and upper respiratory tract infection associated with thrombocytopenia, non-immune hemolytic anemia, and acute kidney injury (AKI). Complete blood count and renal function slowly normalized, with no need for dialysis. She was always normotensive with valid diuresis; her neurological status also rapidly improved. Nasal swab turned out positive for influenza A H1N1; stool test was negative for Shiga toxin-producing Escherichia coli (STEC). The patient was treated with oseltamivir for 5 days with a favorable outcome. Association between hemolytic uremic syndrome (HUS) and H1N1 influenza is poorly reported in literature [ 1 , 2 , 3 , 4 ]. The pathogenic role of the virus in causing HUS is still controversial and debated [ 1 , 2 , 3 , 4 ]. In our patient, complement activity markers (serum C3 and C5b-9) alteration suggested a transient, virus-mediated complement activation.

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Streptococcus pneumoniae-associated Hemolytic Uremic Syndrome

Cited by 3 publications

References 4 publications

Early initiation of eculizumab therapy for Streptococcus pneumoniae–associated hemolytic uremic syndrome

Early initiation of eculizumab therapy for Streptococcus pneumoniae–associated hemolytic uremic syndrome

Typical and Atypical Hemolytic Uremic Syndrome in the Critically Ill

Influenza-associated hemolytic uremic syndrome: The pathogenic role of the virus

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