Streptococcus pneumoniae Endopeptidase O Promotes the Clearance of Staphylococcus aureus and Streptococcus pneumoniae via SH2 Domain-Containing Inositol Phosphatase 1-Mediated Complement Receptor 3 Upregulation

Li, Sijie; Zhang, Hong; Xiao, Jiangming; Yuan, Taixian; Shu, Zhaoche; Min, Yajun; Xu, Wenchun; Yin, Yibing; Xue-mei, Zhang

doi:10.3389/fcimb.2020.00358

Cited by 4 publications

(3 citation statements)

References 44 publications

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“…INPPD5, also known as SHIP1, was previously analyzed in numerous studies, and is also implicated to have a role in immune response [ 63 ]. The role of this gene is closely linked to IL10 and several important pathways [ 64 ], resulting in modifying effects in the case of the clearance of S. aureus and S. pneumoniae [ 65 ], as well as in the pathogenesis of Pseudomonas aeruginosa [ 66 ], Epstein–Barr virus [ 67 ], cytomegalovirus [ 68 , 69 , 70 ], or even immunity to helminth infection in mice [ 71 ].…”

Section: Discussionmentioning

confidence: 99%

Genome-Wide Meta-Analysis Identifies Multiple Novel Rare Variants to Predict Common Human Infectious Diseases Risk

Gelemanović

Ardalić

Pribisalić

et al. 2023

IJMS

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Infectious diseases still threaten global human health, and host genetic factors have been indicated as determining risk factors for observed variations in disease susceptibility, severity, and outcome. We performed a genome-wide meta-analysis on 4624 subjects from the 10,001 Dalmatians cohort, with 14 infection-related traits. Despite a rather small number of cases in some instances, we detected 29 infection-related genetic associations, mostly belonging to rare variants. Notably, the list included the genes CD28, INPP5D, ITPKB, MACROD2, and RSF1, all of which have known roles in the immune response. Expanding our knowledge on rare variants could contribute to the development of genetic panels that could assist in predicting an individual’s life-long susceptibility to major infectious diseases. In addition, longitudinal biobanks are an interesting source of information for identifying the host genetic variants involved in infectious disease susceptibility and severity. Since infectious diseases continue to act as a selective pressure on our genomes, there is a constant need for a large consortium of biobanks with access to genetic and environmental data to further elucidate the complex mechanisms behind host–pathogen interactions and infectious disease susceptibility.

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Section: Discussionmentioning

confidence: 99%

Genome-Wide Meta-Analysis Identifies Multiple Novel Rare Variants to Predict Common Human Infectious Diseases Risk

Gelemanović

Ardalić

Pribisalić

et al. 2023

IJMS

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“…SHIP1 also has been shown to modulate complement receptor 3 (CR3)-mediated phagocytosis in macrophages [ 134 , 138 , 141 ]. CR3 (also known as CD11b/CD18 or Mac-1) is a major phagocytic receptor in the complement system, a large family of proteins that are activated in a cascade-like manner in response to pathogens by the innate immune system.…”

Section: Ship1 Regulates Microglia Function and Activationmentioning

confidence: 99%

Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease

Terzioglu,

Young-Pearse

2023

Mol Neurodegeneration

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Recent genetic studies on Alzheimer’s disease (AD) have brought microglia under the spotlight, as loci associated with AD risk are enriched in genes expressed in microglia. Several of these genes have been recognized for their central roles in microglial functions. Increasing evidence suggests that SHIP1, the protein encoded by the AD-associated gene INPP5D, is an important regulator of microglial phagocytosis and immune response. A recent study from our group identified SHIP1 as a negative regulator of the NLRP3 inflammasome in human iPSC-derived microglial cells (iMGs). In addition, we found evidence for a connection between SHIP1 activity and inflammasome activation in the AD brain. The NLRP3 inflammasome is a multiprotein complex that induces the secretion of pro-inflammatory cytokines as part of innate immune responses against pathogens and endogenous damage signals. Previously published studies have suggested that the NLRP3 inflammasome is activated in AD and contributes to AD-related pathology. Here, we provide an overview of the current understanding of the microglial NLRP3 inflammasome in the context of AD-related inflammation. We then review the known intracellular functions of SHIP1, including its role in phosphoinositide signaling, interactions with microglial phagocytic receptors such as TREM2 and evidence for its intersection with NLRP3 inflammasome signaling. Through rigorous examination of the intricate connections between microglial signaling pathways across several experimental systems and postmortem analyses, the field will be better equipped to tailor newly emerging therapeutic strategies targeting microglia in neurodegenerative diseases.

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“…The function of the virulence protein endopeptidase O (PepO) was adjusted by miR-155 through activation of the TLR2/NF-κB pathway [ 67 ]. PepO is a ubiquitously expressed pneumococcal virulence protein which can regulate the adhesion and invasion of Streptococcus pneumoniae ( S. pneumoniae ) [ 68 ]. PepO-induced phagocytosis was attenuated in cells transfected with miR-155 inhibitors, while it was ameliorated following treatment with mimics.…”

Section: Introductionmentioning

confidence: 99%

The current landscape of microRNAs (miRNAs) in bacterial pneumonia: opportunities and challenges

2022

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MicroRNAs (miRNAs), which were initially discovered in Caenorhabditis elegans, can regulate gene expression by recognizing cognate sequences and interfering with the transcriptional or translational machinery. The application of bioinformatics tools for structural analysis and target prediction has largely driven the investigation of certain miRNAs. Notably, it has been found that certain miRNAs which are widely involved in the inflammatory response and immune regulation are closely associated with the occurrence, development, and outcome of bacterial pneumonia. It has been shown that certain miRNA techniques can be used to identify related targets and explore associated signal transduction pathways. This enhances the understanding of bacterial pneumonia, notably for “refractory” or drug-resistant bacterial pneumonia. Although these miRNA-based methods may provide a basis for the clinical diagnosis and treatment of this disease, they still face various challenges, such as low sensitivity, poor specificity, low silencing efficiency, off-target effects, and toxic reactions. The opportunities and challenges of these methods have been completely reviewed, notably in bacterial pneumonia. With the continuous improvement of the current technology, the miRNA-based methods may surmount the aforementioned limitations, providing promising support for the clinical diagnosis and treatment of “refractory” or drug-resistant bacterial pneumonia.

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Streptococcus pneumoniae Endopeptidase O Promotes the Clearance of Staphylococcus aureus and Streptococcus pneumoniae via SH2 Domain-Containing Inositol Phosphatase 1-Mediated Complement Receptor 3 Upregulation

Cited by 4 publications

References 44 publications

Genome-Wide Meta-Analysis Identifies Multiple Novel Rare Variants to Predict Common Human Infectious Diseases Risk

Genome-Wide Meta-Analysis Identifies Multiple Novel Rare Variants to Predict Common Human Infectious Diseases Risk

Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease

The current landscape of microRNAs (miRNAs) in bacterial pneumonia: opportunities and challenges

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