Streptococcus pyogenes infections in Spanish children before and after the COVID pandemic. Coming back to the previous incidence

Calle, María de Ceano-Vivas La; Gutiérrez, Miguel; Mellado-Sola, Isabel; Sánchez, Paula García; Grandioso, David; Calvo, Cristina; López, Rosario López; Bueno-Barriocanal, Marta; Domínguez, José Antonio Ruiz; Miguel, Begoña de

doi:10.1016/j.eimc.2023.04.003

Cited by 7 publications

(1 citation statement)

References 9 publications

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“…The observed increased rates of infection along with the higher morbidity in the pediatric age group has led to an increase in iGAS notifications in children, particularly in those below 10 years of age [4][5][6][7]. Even though during the pandemic years of COVID-19, respiratory infections, including GAS, dramatically decreased due to lockdown, social distancing and the use of masks [8], a recent upsurge has been observed in Europe [5][6][7]. Early December 2022, the United Kingdom Health Security Agency (UKH-SA) published a surveillance report on an unusual incidence of GAS tonsilitis, scarlet fever and simultaneously of iGAS infections with high morbidity and mortality and issued a warning to parents and clinicians about the high iGAS incidence among children [7,9].…”

Section: Epidemiologymentioning

confidence: 99%

Group A Streptococcus invasive infection in children: Epidemiologic changes and implications

Ramos Amador,

Berzosa Sánchez,

Illán Ramos

2023

Rev Esp Quimioter

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Group A Streptococcus (GAS) can cause a broad array of clinical manifestations and complications. Recently, in post COVID-19 postpandemic months, there has been an increased incidence and severity of invasive infections in the pediatric age group in Spain and other European countries with high morbidity, affecting mostly to young children, associated with seasonal peaks in incidence of viral respiratory pathogens. The increased in incidence and severity has not been associated with predominant GAS strains, but rather to the lack of immunity to both GAS and common viral respiratory infections due to isolation measures to prevent COVID-19. Due to the nonspecific initial clinical manifestations a high index of suspicion is necessary in order to initiate a prompt medical and surgical treatment when necessary to improve the outcome. Prevention strategies are needed as well as continuous microbiological surveillance of iGAS strains.

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Section: Epidemiologymentioning

confidence: 99%

Group A Streptococcus invasive infection in children: Epidemiologic changes and implications

Ramos Amador,

Berzosa Sánchez,

Illán Ramos

2023

Rev Esp Quimioter

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Assessing the influence of the COVID-19 pandemic on the incidence, clinical presentation, and clindamycin resistance rates of Streptococcus pyogenes infections

Marco,

Canela,

Brey

et al. 2024

IJID Regions

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Diagnostic and prognostic value of heparin-binding protein in pediatric community-acquired pneumonia

Mohamed,

Elmeazawy,

Sharaby

et al. 2024

Egypt Pediatric Association Gaz

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Background Community-acquired pneumonia (CAP) and its associated complications pose a noteworthy public health apprehension in the pediatric population, leading to considerable morbidity and mortality. The objective of this study was to assess the diagnostic and prognostic value of heparin-binding protein (HBP) as a promising biomarker in children hospitalized with CAP. Methods This prospective, single-center study included 50 children admitted to the Pediatric Pulmonology Unit between April 2023 and January 2024 with a diagnosis of CAP, as well as age-matched 50 healthy children as a control group. Demographic, clinical, and laboratory data were recorded. The measurement of serum HBP was conducted upon admission utilizing the enzyme-linked immunosorbent assay technique. Results Serum HBP was elevated in the CAP group in comparison to the control group (p < 0.001). Out of 50 patients, 27 (54.0%) had non-complicated pneumonia, and 23 (46.0%) had complicated pneumonia. The levels of HBP were significantly elevated in patients compared to the healthy control group and even higher in patients with complicated CAP compared to those with non-complicated CAP (p < 0.001). Analysis of the ROC curve revealed that the HBP level of ≥ 34.97 ng/ml was linked to a significantly higher AUC of 0.837 (95% CI 0.722–0.951, P < 0.001). Conclusion The level of HBP was observed to be notably elevated in patients as compared to the healthy control, thereby indicating its potential applicability in the early detection of CAP. Moreover, elevated HBP was an independent prognostic factor for complicated CAP in children.

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Streptococcus pyogenes infections in Spanish children before and after the COVID pandemic. Coming back to the previous incidence

Cited by 7 publications

References 9 publications

Group A Streptococcus invasive infection in children: Epidemiologic changes and implications

Group A Streptococcus invasive infection in children: Epidemiologic changes and implications

Assessing the influence of the COVID-19 pandemic on the incidence, clinical presentation, and clindamycin resistance rates of Streptococcus pyogenes infections

Diagnostic and prognostic value of heparin-binding protein in pediatric community-acquired pneumonia

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