2022
DOI: 10.1038/s41598-022-18227-3
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Streptococcus suis TrpX is part of a tryptophan uptake system, and its expression is regulated by a T-box regulatory element

Abstract: Streptococcus suis, a common member of the porcine respiratory microbiota, can cause life-threatening diseases in pigs as well as humans. A previous study identified the gene trpX as conditionally essential for in vivo survival by intrathecal infection of pigs with a transposon library of S. suis strain 10. Here, we characterized trpX, encoding a putative tryptophan/tyrosine transport system substrate-binding protein, in more detail. We compared growth capacities of the isogenic trpX-deficient mutant derivativ… Show more

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“…Therefore, e.g., tryptophan transporters are crucial for pathogenesis. Without the substratebinding protein TrpX of its tryptophan ABC transporter TrpXYZ, S. suis is not able to survive in tryptophan-limited conditions [127] or in porcine blood [50]. Therefore, TrpX significantly contributes to nutrient acquisition and bacterial growth during infection.…”
Section: Amino Acid Metabolismmentioning
confidence: 99%
“…Therefore, e.g., tryptophan transporters are crucial for pathogenesis. Without the substratebinding protein TrpX of its tryptophan ABC transporter TrpXYZ, S. suis is not able to survive in tryptophan-limited conditions [127] or in porcine blood [50]. Therefore, TrpX significantly contributes to nutrient acquisition and bacterial growth during infection.…”
Section: Amino Acid Metabolismmentioning
confidence: 99%