Streptococcus thermophilus Inhibits Colorectal Tumorigenesis Through Secreting β-Galactosidase

Li, Qing; Hu, Wei; Liu, Weixin; Zhao, Liuyang; Huang, Dan; Liu, Xiaodong; Chan, Hung; Zhang, Yuchen; Zeng, Judeng; Coker, Olabisi Oluwabukola; Kang, Wei; Ng, Simon Siu Man; Zhang, Lin; Wong, Sunny H.; Gin, Tony; Chan, Matthew Tak Vai; Wu, Jian‐Lin; Yu, Jun; Wu, William

doi:10.1053/j.gastro.2020.09.003

Cited by 154 publications

(120 citation statements)

References 24 publications

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“…In addition, Li et al recently demonstrated an inhibitory role of Streptococcus thermophilus on colorectal carcinogenesis via the action of β-galactosidase using in vitro and murine models. These results would support a potential prophylactic use of fermented dairy that contains the bacterium in colorectal cancer prevention [ 105 ]. Nevertheless, the role of fermented and non-fermented dairy products consumption in cancer development remains controversial [ 99 , 106 , 107 ].…”

Section: Prolonged Health Implications Of Lactose Intolerancementioning

confidence: 72%

Development of Personalized Nutrition: Applications in Lactose Intolerance Diagnosis and Management

et al. 2021

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Recent discoveries in the “omics” field and the growing focus on preventive health have opened new avenues for personalized nutrition (PN), which is becoming an important theme in the strategic plans of organizations that are active in healthcare, food, and nutrition research. PN holds great potential for individual health optimization, disease management, public health interventions, and product innovation. However, there are still multiple challenges to overcome before PN can be truly embraced by the public and healthcare stakeholders. The diagnosis and management of lactose intolerance (LI), a common condition with a strong inter-individual component, is explored as an interesting example for the potential role of these technologies and the challenges of PN. From the development of genetic and metabolomic LI diagnostic tests that can be carried out in the home, to advances in the understanding of LI pathology and individualized treatment optimization, PN in LI care has shown substantial progress. However, there are still many research gaps to address, including the understanding of epigenetic regulation of lactase expression and how lactose is metabolized by the gut microbiota, in order to achieve better LI detection and effective therapeutic interventions to reverse the potential health consequences of LI.

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Section: Prolonged Health Implications Of Lactose Intolerancementioning

confidence: 72%

Development of Personalized Nutrition: Applications in Lactose Intolerance Diagnosis and Management

et al. 2021

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“…These enzymes might be potential industrial GHs. Moreover, β‐galactosidase from Streptococcus thermophilus have been reported to have tumor suppressive effects (Li et al., 2021). Therefore, future research is needed on effects of the predicted enzymes related to galactans degradation on human health, whereas structural changes and metabolites after galactans degradation also require attention.…”

Section: Discussionmentioning

confidence: 99%

Utilization of four galactans by Bacteroides thetaiotaomicron A4 based on transcriptome

Song

Zhang

et al. 2021

Food Frontiers

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The interaction between gut microbiota and polysaccharide is being paid more and more attention. Galactan is a kind of polysaccharide mainly composed of galactose, and it has been shown to play a significant role in regulating gut microbiota. Bacteroides thetaiotaomicron is considered as the best degrader of polysaccharides. The purpose of this paper was to investigate the utilization of four different galactans, including agarose, carrageenan, arabinogalactan, and glucofucogalactan, by our own isolated B. thetaiotaomicron A4. Samples of cultures grown on either four galactans groups or control groups were collected. The change of OD600, pH, and short‐chain fatty acids (SCFAs) during fermentation were determined, and growth curve and transcriptome of B. thetaiotaomicron A4 were studied. B. thetaiotaomicron A4 could utilize the four galactans and grew well on them, with carrageenan being most utilized, followed by arabinogalactan, glucofucogalactan, and agarose. SCFAs (mainly acetic acid and propionic acid) produced along with the decreased pH during fermentation. A large number of genes of B. thetaiotaomicron A4 were upregulated and functioned in different pathways during the degradation of the four galactans. The carbohydrate metabolism‐related pathways of B. thetaiotaomicron A4 were enriched after feeding the four galactans, although the specific pathways were different among four galactans groups. The different structural characteristics of four galactans required that B. thetaiotaomicron A4 could excrete corresponding enzymes to degrade them. These results help to understand the interaction between galactans and gut microbe.

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“…In another study, the microorganism Streptococcus thermophilus (19258) showed apoptosis, antiproliferation, and cell cycle arrest effect on HCT116, HT-29, and Caco-2 cancerous cells. These effects are found to be driven by the production of galactose (which is produced primarily by the probiotic bacteria), followed by interfering with energy homeostasis and establishing an anti-Warburg effect phenotype [38].…”

Section: Restricting the Growth Of Cancerous Cellsmentioning

confidence: 99%

Probiotics: A Promising Candidate for Management of Colorectal Cancer

Tripathy

Dash

Kancharla³

et al. 2021

Cancers

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Colorectal cancer (CRC) is the World’s third most frequently diagnosed cancer type. It accounted for about 9.4% mortality out of the total incidences of cancer in the year 2020. According to estimated facts by World Health Organization (WHO), by 2030, 27 million new CRC cases, 17 million deaths, and around 75 million people living with the disease will appear. The facts and evidence that establish a link between the intestinal microflora and the occurrence of CRC are quite intuitive. Current shortcomings of chemo- and radiotherapies and the unavailability of appropriate treatment strategies for CRC are becoming the driving force to search for an alternative approach for the prevention, therapy, and management of CRC. Probiotics have been used for a long time due to their beneficial health effects, and now, it has become a popular candidate for the preventive and therapeutic treatment of CRC. The probiotics adopt different strategies such as the improvement of the intestinal barrier function, balancing of natural gut microflora, secretion of anticancer compounds, and degradation of carcinogenic compounds, which are useful in the prophylactic treatment of CRC. The pro-apoptotic ability of probiotics against cancerous cells makes them a potential therapeutic candidate against cancer diseases. Moreover, the immunomodulatory properties of probiotics have created interest among researchers to explore the therapeutic strategy by activating the immune system against cancerous cells. The present review discusses in detail different strategies and mechanisms of probiotics towards the prevention and treatment of CRC.

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Streptococcus thermophilus Inhibits Colorectal Tumorigenesis Through Secreting β-Galactosidase

Cited by 154 publications

References 24 publications

Development of Personalized Nutrition: Applications in Lactose Intolerance Diagnosis and Management

Development of Personalized Nutrition: Applications in Lactose Intolerance Diagnosis and Management

Utilization of four galactans by Bacteroides thetaiotaomicron A4 based on transcriptome

Probiotics: A Promising Candidate for Management of Colorectal Cancer

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