Streptococcus uberis and Staphylococcus aureus forefoot and blood stream co-infection in a haemodialysis patient: a case report

Abstract

BackgroundStreptococcus uberis, the most frequent cause of mastitis in lactating cows, is considered non-pathogenic for humans. Only a few case reports have described human infections with this microorganism, which is notoriously difficult to identify.Case presentationWe report the case of a 75-year-old male haemodialysis patient, who developed a severe foot infection with osteomyelitis and bacteraemia. Both Streptococcus uberis and Staphylococcus aureus were identified in wound secretion and blood samples using mass spectrometry. The presence of Streptococcus uberis was confirmed by superoxide dismutase A sequencing. The patient recovered after amputation of the forefoot and antibiotic treatment with ampicillin/sulbactam. He had probably acquired the infection while walking barefoot on cattle pasture land.ConclusionThis is the first case report of a human infection with Streptococcus uberis with identification of the microorganism using modern molecular technology. We propose that Staphylococcus aureus co-infection was a prerequisite for deep wound and bloodstream infection with Streptococcus uberis.Electronic supplementary materialThe online version of this article (doi:10.1186/s12882-015-0069-6) contains supplementary material, which is available to authorized users.

A Novel Antimicrobial–Phytochemical Conjugate With Antimicrobial Activity Against Streptococcus uberis, Enterococcus faecium, and Enterococcus faecalis

“…The antimicrobial activity of compound Hybrid 1, with sulfamethoxazole as a control, was firstly evaluated towards the three ATCC strains— S. uberis 19436, E. faecium 700221, and E. faecalis 29212—using a protocol developed in our laboratory (Rajamanickam et al, 2019a). S. uberis is the most common bacterial mastitis-causing pathogen in lactating cows worldwide (Leigh, 1999; Valentiny et al, 2015), although Staphylococcus aureus is probably the most common pathogenic bacterium in Canadian dairy farms (Olde Riekerink et al, 2008). As shown in Figure 2A , sulfamethoxazole did not inhibit the growth of S. uberis 19436, which is consistent with previous reports that S. uberis isolates from dairy cows with mastitis are highly resistant to sulfamethoxazole (Phuektes et al, 2001; McDougall et al, 2014).…”

Purification and characterization of ribosomal proteins L27 and L30 having antimicrobial activity produced by theLactobacillus salivariusSGL 03

“…Recently, S. uberis has been found in wound and bloodstream infection in haemodialysis patient (Valentiny et al . ). In addition, from a point of view of food preservation, this microorganism is directly responsible of deterioration of technological quality of cows’ milk (Pecka‐Kielb et al .…”

Globicatella sanguinis Osteomyelitis and Bacteremia: Review of an Emerging Human Pathogen with an Expanding Spectrum of Disease

“…Streptococcus uberis , a major cause of mastitis in cattle, was at that time a rare cause of human disease [11]. A second species implicated in livestock infections, G sulfidifaciens , was later described [12, 13].…”

“…In 1992, on the basis of differences in ecology and 16S rRNA sequence, Collins et al [ 10 ] separated all human strains of Streptococcus uberis into a new genus and species, G sanguinis . Streptococcus uberis , a major cause of mastitis in cattle, was at that time a rare cause of human disease [ 11 ]. A second species implicated in livestock infections, G sulfidifaciens , was later described [ 12 , 13 ].…”