Streptogramins, Oxazolidinones, and Other Inhibitors of Bacterial Protein Synthesis

Mukhtar, Tariq; Wright, Gerard D.

doi:10.1002/chin.200524272

Cited by 22 publications

(31 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This was not explained by the impact of these antibiotics on bacterial growth because PVL was detectable at the cell density achieved (data not shown). These antibiotics have previously been shown to reduce the production of several other toxins (2,5,6,8,25,26,28), possibly through their impact on bacterial protein synthesis and transcription (11,17).…”

mentioning

confidence: 99%

Effect of Antibiotics on Staphylococcus aureus Producing Panton-Valentine Leukocidin

Dumitrescu

Boisset

Badiou

et al. 2007

Antimicrob Agents Chemother

181

120

View full text Add to dashboard Cite

We examined the capacity of Staphylococcus aureus strains to release Panton-Valentine leukocidin (PVL) in the presence of antibiotics. No PVL was detected when S. aureus was incubated at inhibitory concentrations, while subinhibitory concentrations of oxacillin enhanced the PVL level; clindamycin, linezolid, and fusidic acid were inhibitory; and vancomycin had roughly no effect.Staphylococcus aureus is an important human pathogen. It expresses a variety of exoproteins, including Panton-Valentine leukocidin (PVL) (31). While Voyich et al. could not establish clear differences in virulence between isogenic pairs of PVLpositive/negative strains (29), Labandeira-Rey et al. clearly demonstrated the role of PVL as a major determinant of virulence in an acute pneumonia mouse model using other sets of isogenic strains for PVL (13) and thus confirmed the results of the princeps experiments showing that PVL is a virulence factor (15). The apparent discrepancy between these studies basically comes from the choice of the experimental models and the choice of the strains.

show abstract

mentioning

confidence: 99%

Effect of Antibiotics on Staphylococcus aureus Producing Panton-Valentine Leukocidin

Dumitrescu

Boisset

Badiou

et al. 2007

Antimicrob Agents Chemother

181

120

View full text Add to dashboard Cite

show abstract

“…Group A streptogramins (dalfopristin) bind in the peptidyltransferase center (PTC) and interfere with binding of aminoacyltRNAs, which prevents the formation of a peptide bond during the elongation step. Streptogramin B components (quinupristin) bind to the proximal end of the exit tunnel resulting in the release of the small incomplete oligopeptide chains [73,74]. Each compound shows moderate activity, whereas the combination of both drugs demonstrates a synergetic effect.…”

Section: Fig 32 Dalfopristin(a) and Quinupristin(b)mentioning

confidence: 99%

“…The acetylation of the OH group in dalfopristin and its analogues catalyzed by O-acetyltransferases (e.g. virginiamycin acetyltransferase) results in the formation of O-acetyl products that do not have the binding affinity to 50S ribosome subunit [73]. Enzymatic deactivation of quinupristin and its structural homologues proceeds by lactone opening catalyzed by virginiamycin B lyase (Vgb) resulting in the formation of linear products that have lost their antibacterial activity [75].…”

Section: Fig 32 Dalfopristin(a) and Quinupristin(b)mentioning

confidence: 99%

“…On the other hand, the substitution of the 4-oxo-2-piperidinecarboxylic acid fragment in pristinamycin I (Fig. 33) by other heterocyclic amino acids led to the discovery of several new active compounds [73]. An interesting approach to the modification of the streptogramin structure was demonstrated by Mukhtar et al [76].…”

Section: Mir-journalorg Fighting Bacterial Resistancementioning

confidence: 99%

“…This class of compounds was first investigated at DuPont and Volume 4 Number 1 2017 then at Pharmacia [73]. Linezolid and other oxazolidinones bind to the 50S ribosomal subunit and inhibit the process of protein synthesis.…”

Section: Fig 34 Azithromycin (A) and Erythromycin (B)mentioning

confidence: 99%

See 2 more Smart Citations

Fighting bacterial resistance: approaches, challenges, and opportunities in the search for new antibiotics.Part 1. Antibiotics used in clinical practice: mechanisms of action and the development of bacterial resistance

Zhivich

2017

Microbiology Independent Research Journal (MIR Journal)

View full text Add to dashboard Cite

Hundreds of thousands of people are dying every year in the world from infections caused by drug resistant bacteria. Antibiotic resistance is a rapidly increasing problem mostly as a result of the worldwide overuse and misuse of antibiotics for conditions that do not require them. The rapid spread of antibiotic resistance in bacteria makes it necessary to intensify the development of new antibiotics and new methods to combat drug resistant bacteria. The goal of this publication is to review the approaches to finding new antibiotics that are active against drug resistant bacteria. The first part of this review is focused on an analysis of the mechanisms of action of antibiotics that are used in clinical practice as well as the mechanisms of bacterial resistance. The molecular structure and modes of action of these antibiotics are reviewed with examples of detailed mechanisms of drugs interaction with the targets in bacteria. General and specific mechanisms of bacterial resistance to these antibiotics are described. Examples of new antibiotics development active against the drug resistant bacteria are presented.

show abstract

Efficient methods for the synthesis of chiral 2‐oxazolidinones as pharmaceutical building blocks

et al. 2022

View full text Add to dashboard Cite

Although the wide variety of heterocyclic compounds is common knowledge, chiral 2‐oxazolidinones are recognized as some of the most important heterocycles in medicinal chemistry. Many important pharmaceutical molecules have been constructed based on the chiral 2‐oxazolidinone backbone. Therefore, the development of even more efficient catalytic methods for the synthesis of chiral 2‐oxazolidinones remains a very important pursuit in the field of synthetic organic chemistry. This review summarizes the coupling reactions of epoxides and isocyanates for the preparation of 2‐oxazolidinones. Both metal catalysts and organocatalysts promote these reactions. Optically pure 2‐oxazolidinones are prepared from optically pure epoxide substrates via these catalytic methods. A synthetic example of a commercially available pharmaceutical compound utilizing this method is also introduced.

show abstract

Streptogramins, Oxazolidinones, and Other Inhibitors of Bacterial Protein Synthesis

Abstract: For Abstract see ChemInform Abstract in Full Text.

Cited by 22 publications

References 82 publications

Effect of Antibiotics on Staphylococcus aureus Producing Panton-Valentine Leukocidin

Effect of Antibiotics on Staphylococcus aureus Producing Panton-Valentine Leukocidin

Fighting bacterial resistance: approaches, challenges, and opportunities in the search for new antibiotics.Part 1. Antibiotics used in clinical practice: mechanisms of action and the development of bacterial resistance

Efficient methods for the synthesis of chiral 2‐oxazolidinones as pharmaceutical building blocks

Contact Info

Product

Resources

About